Temporal competition between differentiation programs determines cell fate choice

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• dc.contributor.author Kuchina, Annaca
• dc.contributor.author Espinar, Lorenaca
• dc.contributor.author Cagatay, Tolgaca
• dc.contributor.author Balbin, Alejandro O.ca
• dc.contributor.author Zhang, Fangca
• dc.contributor.author Alvarado, Almaca
• dc.contributor.author García Ojalvo, Jordica
• dc.contributor.author Süel, Gürol M.ca
• dc.date.accessioned 2015-12-21T15:48:51Z
• dc.date.available 2015-12-21T15:48:51Z
• dc.date.issued 2011
• dc.description.abstract Multipotent differentiation, where cells adopt one of several possible fates, occurs in diverse systems ranging from bacteria to mammals. This decision-making process is driven by multiple differentiation programs that operate simultaneously in the cell. How these programs interact to govern cell fate choice is poorly understood. To investigate this issue, we simultaneously measured activities of the competing sporulation and competence programs in single Bacillus subtilis cells. This approach revealed that these competing differentiation programs progress independently without cross-regulation before the decision point. Cells seem to arrive at a fate choice through differences in the relative timing between the two programs. To test this proposed dynamic mechanism, we altered the relative timing by engineering artificial cross-regulation between the sporulation and competence circuits. Results suggest a simple model that does not require a checkpoint or intricate cross-regulation before cellular decision-making. Rather, cell fate choice appears to be the outcome of a 'molecular race' between differentiation programs that compete in time, providing a simple dynamic mechanism for decision-making.ca
• dc.format.mimetype application/pdfca
• dc.identifier.citation Kuchina A, Espinar L, Çağatay T, Balbin AO, Zhang F, Alvarado A et al. Temporal competition between differentiation programs determines cell fate choice. Molecular systems biology. 2011;7:557. DOI: 10.1038/msb.2011.88ca
• dc.identifier.doi http://dx.doi.org/10.1038/msb.2011.88
• dc.identifier.issn 1744-4292
• dc.identifier.uri http://hdl.handle.net/10230/25493
• dc.language.iso engca
• dc.publisher Nature Publishing Groupca
• dc.relation.ispartof Molecular systems biology. 2011;7:557
• dc.rights © 2011 EMBO and Macmillan Publishers Limitedca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/ca
• dc.subject.keyword Cellular decision-making
• dc.subject.keyword Differentiation dynamics
• dc.subject.keyword Interactions between signaling pathways
• dc.subject.keyword Quantitative single-cell dynamics
• dc.subject.other Fongs -- Genèticaca
• dc.subject.other Meiosica
• dc.subject.other Regulació genèticaca
• dc.title Temporal competition between differentiation programs determines cell fate choiceca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca