Integrated in silico analyses identify PUF60 and SF3A3 as new spliceosome-related breast cancer RNA-binding proteins

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• dc.contributor.author García-Cárdenas, Jennyfer M.
• dc.contributor.author Armendáriz-Castillo, Isaac
• dc.contributor.author Pérez-Villa, Andy
• dc.contributor.author Indacochea Cusirramos, Alberto
• dc.contributor.author Jácome-Alvarado, Andrea
• dc.contributor.author López-Cortés, Andrés
• dc.contributor.author Guerrero, Santiago
• dc.date.accessioned 2022-05-24T10:33:17Z
• dc.date.available 2022-05-24T10:33:17Z
• dc.date.issued 2022
• dc.description.abstract More women are diagnosed with breast cancer (BC) than any other type of cancer. Although large-scale efforts have completely redefined cancer, a cure remains unattainable. In that respect, new molecular functions of the cell should be investigated, such as post-transcriptional regulation. RNA-binding proteins (RBPs) are emerging as critical post-transcriptional modulators of tumorigenesis, but only a few have clear roles in BC. To recognize new putative breast cancer RNA-binding proteins, we performed integrated in silico analyses of all human RBPs (n = 1392) in three major cancer databases and identified five putative BC RBPs (PUF60, TFRC, KPNB1, NSF, and SF3A3), which showed robust oncogenic features related to their genomic alterations, immunohistochemical changes, high interconnectivity with cancer driver genes (CDGs), and tumor vulnerabilities. Interestingly, some of these RBPs have never been studied in BC, but their oncogenic functions have been described in other cancer types. Subsequent analyses revealed PUF60 and SF3A3 as central elements of a spliceosome-related cluster involving RBPs and CDGs. Further research should focus on the mechanisms by which these proteins could promote breast tumorigenesis, with the potential to reveal new therapeutic pathways along with novel drug-development strategies.
• dc.description.sponsorship This research received no external funding
• dc.format.mimetype application/pdf
• dc.identifier.citation García-Cárdenas JM, Armendáriz-Castillo I, Pérez-Villa A, Indacochea A, Jácome-Alvarado A, López-Cortés A. Integrated in silico analyses identify PUF60 and SF3A3 as new spliceosome-related breast cancer RNA-binding proteins. Biology (Basel). 2022 Mar 22;11(4):481. DOI:10.3390/biology11040481
• dc.identifier.doi http://dx.doi.org/10.3390/biology11040481
• dc.identifier.issn 2079-7737
• dc.identifier.uri http://hdl.handle.net/10230/53227
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights © 2022 by Jennyfer M. García-Cárdenas et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Mama -- Càncer
• dc.subject.other Tumors
• dc.subject.other Proteïnes
• dc.title Integrated in silico analyses identify PUF60 and SF3A3 as new spliceosome-related breast cancer RNA-binding proteins
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion