Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases

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• dc.contributor.author Bousquet, Jean
• dc.contributor.author Torre Fornell, Rafael de la
• dc.contributor.author Pizarro Lozano, Mª Nieves
• dc.contributor.author Antó i Boqué, Josep Maria
• dc.date.accessioned 2021-02-17T06:51:36Z
• dc.date.available 2021-02-17T06:51:36Z
• dc.date.issued 2020
• dc.description.abstract COVID-19 is described in a clinical case involving a patient who proposed the hypothesis that Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-interacting nutrients may help to prevent severe COVID-19 symptoms. Capsules of broccoli seeds containing glucoraphanin were being taken before the onset of SARS-CoV-2 infection and were continued daily for over a month after the first COVID-19 symptoms. They were found to reduce many of the symptoms rapidly and for a duration of 6-12 h by repeated dosing. When the patient was stable but still suffering from cough and nasal obstruction when not taking the broccoli capsules, a double-blind induced cough challenge confirmed the speed of onset of the capsules (less than 10 min). A second clinical case with lower broccoli doses carried out during the cytokine storm confirmed the clinical benefits already observed. A third clinical case showed similar effects at the onset of symptoms. In the first clinical trial, we used a dose of under 600 μmol per day of glucoraphanin. However, such a high dose may induce pharmacologic effects that require careful examination before the performance of any study. It is likely that the fast onset of action is mediated through the TRPA1 channel. These experimental clinical cases represent a proof-of-concept confirming the hypothesis that Nrf2-interacting nutrients are effective in COVID-19. However, this cannot be used in practice before the availability of further safety data, and confirmation is necessary through proper trials on efficacy and safety.
• dc.format.mimetype application/pdf
• dc.identifier.citation Bousquet J, Le Moing V, Blain H, Czarlewski W, Zuberbier T, de la Torre R et al. Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases. World Allergy Organ J. 2020; 14(1):100498. DOI: 10.1016/j.waojou.2020.100498
• dc.identifier.doi http://dx.doi.org/10.1016/j.waojou.2020.100498
• dc.identifier.issn 1939-4551
• dc.identifier.uri http://hdl.handle.net/10230/46507
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof World Allergy Organ J. 2020; 14(1):100498
• dc.rights © 2020 The Author(s). Published by Elsevier Inc. on behalf ofWorld Allergy Organization. This is an open access article under the CC BYlicense (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword ACE, Angiotensin converting enzyme
• dc.subject.keyword AT1R, Angiotensin II receptor type 1
• dc.subject.keyword BMI, Body mass index
• dc.subject.keyword Broccoli
• dc.subject.keyword Broccoli, Broccoli seed capsules
• dc.subject.keyword COVID-19
• dc.subject.keyword COVID-19, Coronavirus 19 disease
• dc.subject.keyword Cough challenge
• dc.subject.keyword NAPQI, N-acetyl-p-benzoquinone imine
• dc.subject.keyword Nrf2
• dc.subject.keyword Nrf2, Nuclear factor (erythroid-derived 2)-like 2
• dc.subject.keyword SARS, Severe acute respiratory syndrome
• dc.subject.keyword SARS-Cov-2, Severe acute respiratory syndrome coronavirus 2
• dc.subject.keyword TRP, Transient receptor potential
• dc.subject.keyword TRPA1
• dc.subject.keyword TRPA1, Transient receptor potential ankyrin 1
• dc.subject.keyword TRPV1
• dc.subject.keyword TRPV1, Transient receptor potential vanillin 1
• dc.subject.keyword VAS, Visual analogue scale
• dc.title Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion