Short-term exposure to traffic-related air pollution and dynamic brain connectivity in adolescents

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• dc.contributor.author López Vicente, Mònica, 1988-
• dc.contributor.author Kusters, Michelle S.W.
• dc.contributor.author Petricola, Sami
• dc.contributor.author Tiemeier, Henning
• dc.contributor.author Muetzel, Ryan L.
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2025-07-31T07:21:49Z
• dc.date.available 2025-07-31T07:21:49Z
• dc.date.issued 2025
• dc.description.abstract There is some evidence which suggests short-term effects of traffic-related air pollution on brain function in adults. We aimed to examine these associations at ages 10 and 14 years using dynamic functional brain connectivity. We included participants from a population-based birth cohort with brain connectivity and air pollution data at home (n = 3608) or school (n = 2305) in at least one visit. We used land use regression models to estimate levels of air pollutants, including nitrogen oxides (NOX) and particulate matter (PM), during the week before the outcome measurement. Using resting-state functional magnetic resonance imaging data, we generated five connectivity patterns. We calculated the mean time spent in each pattern for each participant and visit. We performed linear mixed effects models adjusted for relevant confounders. The median levels of NOX at the two visits and at home and school were between 36 and 47 μg/m3 and the median levels of PM2.5 were between 11 and 12 μg/m3. We found a weak association between higher air pollution exposure and less time spent in a low modularized connectivity pattern (e.g. coefficient=-0.031 [95 % confidence interval=-0.056; -0.006] per 20 μg/m3 increase in NOX at home). However, this association did not remain after multiple testing correction. Further research that explores these associations at other exposure levels and other age periods is warranted.
• dc.description.sponsorship This study was supported by the Project IJC2020–045355-I, funded by MCIN/AEI/10.13039/501100011033 and by the European Union NextGenerationEU/PRTR (MLV). This study was co-financed by the Agencia Estatal de Investigación (AEI) and the European Social Fund (FSE) "EL FSE invierte en tu futuro" with reference number PRE2020-092005, according to the Resolution of the Presidency of the AEI, by which grants are awarded for pre-doctoral contracts for the training of doctors, call 2020 (MSWK). Generation R Neuroimaging was supported by the Sophia Foundation project S18–20 (RLM), the Erasmus MC Fellowship (RLM), and The Netherlands Organization for Scientific Research (2021.042, Snellius, RLM). The work of HT is supported by the European Union’s HorizonEurope Research and Innovation Programme (FAMILY, grant agreement No 101057529). MG was funded by a Miguel Servet II fellowship (CPII18/00018) from the Spanish Institute of Health Carlos III. The geocodification of the addresses of the study participants and the air pollution estimations were done within the framework of a project funded by the Health Effects Institute (HEI) (Assistance Award No. R-82811201) and by the Spanish Institute of Health Carlos III (PI20/01695 including FEDER funds). We acknowledge support from the grant CEX2023-0001290-S funded by MCIN/AEI/ 10.13039/501100011033, the Generalitat de Catalunya through the CERCA Program, and the Ministry of Research and Universities of the Government of Catalonia (2021 SGR 01564).
• dc.format.mimetype application/pdf
• dc.identifier.citation López-Vicente M, Kusters MSW, Petricola S, Tiemeier H, Muetzel RL, Guxens M. Short-term exposure to traffic-related air pollution and dynamic brain connectivity in adolescents. Dev Cogn Neurosci. 2025 May 27;74:101574. DOI: 10.1016/j.dcn.2025.101574
• dc.identifier.doi http://dx.doi.org/10.1016/j.dcn.2025.101574
• dc.identifier.issn 1878-9293
• dc.identifier.uri http://hdl.handle.net/10230/71050
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Dev Cogn Neurosci. 2025 May 27;74:101574
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101057529
• dc.rights © 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Adolescent
• dc.subject.keyword Air pollution
• dc.subject.keyword Brain
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Magnetic Resonance Imaging
• dc.subject.keyword Short-term
• dc.title Short-term exposure to traffic-related air pollution and dynamic brain connectivity in adolescents
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion