Genomic insights into the Ixodes scapularis tick vector of Lyme disease

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• dc.contributor.author Gulia-Nuss, Monika
• dc.contributor.author Tornador Antolin, Cristian, 1979-
• dc.contributor.author Hill, Catherine A.
• dc.date.accessioned 2024-01-23T07:15:49Z
• dc.date.available 2024-01-23T07:15:49Z
• dc.date.issued 2016
• dc.description Includes supplementary materials for the online appendix.
• dc.description.abstract Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
• dc.description.sponsorship This project has been funded in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services (NIAID, NIH, DHHS) under contract numbers N01-AI30071, HHSN272200900007C, HHSN266200400001C and 5R01GM77117-5. Its contents are solely the responsibility of the authors and do not represent the official views of the NIH. Additional grants and contracts supporting work described in this manuscript were from the NIH-NIAID (HHSN266200400039C and HHSN272200900039C) to F.H.C., and a subcontract under HHSN272200900039C to C.A.H. and J.M.M., the Australian Research Council Discovery Project (DP120100240) to S.C.B. and R.S., the Ministerio de Ciencia e Innovación of Spain (BFU2007–6292; BFU2010–15484) to J.R., BIO2009–07990 and BIO2012–37926 to J.V. NIH-1R01AI090062 to Y.P., L.S., and J.K., NIH 1R21AI096268 and NSF IOS-0949194 to R.M.R., the Xunta de Galicia of Spain (10PXIB918057PR) to J.M.C.T. and M.T., BFU2011–23896 and EU FP7 ANTIGONE (278976) to J.F., the USDA-NRI/CREES (2008-35302-18820) and Texas AgriLife Research Vector Biology grant to P.V.P. and European Research Council Starting Independent Researcher Grant (205202) to R.B., J.M.R was supported by the intramural program of the NIAID, R.M.W. by a Marie Curie International Outgoing Fellowship PIOF-GA-2011–303312, E.M.Z. by Swiss National Science Foundation awards 31003A-125350 and 31003A-143936, J.M.G. by an NIH-NCATS award TL1 TR000162 and NSF Graduate Research Fellowship (DGE 1333468), V.C. by a Boehringer Ingelheim Ph.D. Fellowship, F.G.V. by a Fundação para a Ciência e a Tecnologia, Portugal fellowship (SFRH/BD/22360/2005), C.J.P.G. and F.H. by The Lundbeck Foundation (Denmark), and J.J.G. by NIH awards HHSN272200900040C, R01AI017828 and R01AI043006. Support from the Broad Genomics Platform is gratefully acknowledged.
• dc.format.mimetype application/pdf
• dc.identifier.citation Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, et al. Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nat Commun. 2016 Feb 9;7(1):10507. DOI: 10.1038/ncomms10507
• dc.identifier.doi http://dx.doi.org/10.1038/ncomms10507
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/58786
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature Communications . 2016 Feb 9;7(1):10507
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/205202
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/BFU2006-6292
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2010–15484
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2009–07990
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012–37926
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/303312
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/125350
• dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Paparres
• dc.subject.other Lyme, Malaltia de
• dc.subject.other Genomes
• dc.title Genomic insights into the Ixodes scapularis tick vector of Lyme disease
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion