A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
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- dc.contributor.author Li, Shaobo
- dc.contributor.author Aguilar Lacasaña, Sofía
- dc.contributor.author Cosín Tomàs, Marta
- dc.contributor.author Vrijheid, Martine
- dc.contributor.author Wiemels, Joseph L.
- dc.date.accessioned 2024-06-19T06:05:24Z
- dc.date.available 2024-06-19T06:05:24Z
- dc.date.issued 2024
- dc.description.abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.
- dc.format.mimetype application/pdf
- dc.identifier.citation Li S, Spitz N, Ghantous A, Abrishamcar S, Reimann B, Marques I, et al. A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation. Commun Biol. 2024 Jan 9;7(1):66. DOI: 10.1038/s42003-023-05698-x
- dc.identifier.doi http://dx.doi.org/10.1038/s42003-023-05698-x
- dc.identifier.issn 2399-3642
- dc.identifier.uri http://hdl.handle.net/10230/60515
- dc.language.iso eng
- dc.publisher Nature Research
- dc.relation.ispartof Commun Biol. 2024 Jan 9;7(1):66
- dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Epidemiology
- dc.subject.keyword Intrauterine growth
- dc.subject.keyword Risk factors
- dc.title A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion