Calculating daily dose in the Observational Medical Outcomes Partnership Common Data Model

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  • dc.contributor.author Burkard, Theresa
  • dc.contributor.author López-Güell, Kim
  • dc.contributor.author Gorbachev, Artem
  • dc.contributor.author Bellas, Lucía
  • dc.contributor.author Jödicke, Annika M.
  • dc.contributor.author Burn, Edward
  • dc.contributor.author de Ridder, Maria
  • dc.contributor.author Mosseveld, Mees
  • dc.contributor.author Gratton, Jasmine
  • dc.contributor.author Seager, Sarah
  • dc.contributor.author Vojinovic, Dina
  • dc.contributor.author Mayer, Miguel Ángel, 1960-
  • dc.contributor.author Ramírez Anguita, Juan Manuel
  • dc.contributor.author Leis Machín, Angela 1974-
  • dc.contributor.author Oja, Marek
  • dc.contributor.author Kolde, Raivo
  • dc.contributor.author Bonadt, Klaus
  • dc.contributor.author Prieto-Alhambra, Daniel
  • dc.contributor.author Reich, Christian
  • dc.contributor.author Català, Martí
  • dc.date.accessioned 2025-07-11T07:03:01Z
  • dc.date.available 2025-07-11T07:03:01Z
  • dc.date.issued 2024
  • dc.description.abstract Purpose: We aimed to develop a standardized method to calculate daily dose (i.e., the amount of drug a patient was exposed to per day) of any drug on a global scale using only drug information of typical observational data in the Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) and a single reference table from Observational Health Data Sciences And Informatics (OHDSI). Materials and methods: The OMOP DRUG_STRENGTH reference table contains information on the strength or concentration of drugs, whereas the OMOP DRUG_EXPOSURE table contains information on patients' drug prescriptions or dispensations/claims. Based on DRUG_EXPOSURE data from the primary care databases Clinical Practice Research Datalink GOLD (United Kingdom) and Integrated Primary Care Information (IPCI, The Netherlands) and healthcare claims from PharMetrics® Plus for Academics (USA), we developed four formulas to calculate daily dose given different DRUG_STRENGTH reference table information. We tested the dose formulas by comparing the calculated median daily dose to the World Health Organization (WHO) Defined Daily Dose (DDD) for six different ingredients in those three databases and additional four international databases representing a variety of healthcare settings: MAITT (Estonia, healthcare claims and discharge summaries), IQVIA Disease Analyzer Germany (outpatient data), IQVIA Longitudinal Patient Database Belgium (outpatient data), and IMASIS Parc Salut (Spain, hospital data). Finally, in each database, we assessed the proportion of drug records for which daily dose calculations were possible using the suggested formulas. Results: Applying the dose formulas, we obtained median daily doses that generally matched the WHO DDD definitions. Our dose formulas were applicable to >85% of drug records in all but one of the assessed databases. Conclusion: We have established and implemented a standardized daily dose calculation in OMOP CDM providing reliable and reproducible results.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Burkard T, López-Güell K, Gorbachev A, Bellas L, Jödicke AM, Burn E, et al. Calculating daily dose in the Observational Medical Outcomes Partnership Common Data Model. Pharmacoepidemiol Drug Saf. 2024 Jun;33(6):e5809. DOI: 10.1002/pds.5809
  • dc.identifier.doi http://dx.doi.org/10.1002/pds.5809
  • dc.identifier.issn 1053-8569
  • dc.identifier.uri http://hdl.handle.net/10230/70894
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof Pharmacoepidemiol Drug Saf. 2024 Jun;33(6):e5809
  • dc.rights © 2024 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword OMOP
  • dc.subject.keyword WHO DDD
  • dc.subject.keyword Common data model
  • dc.subject.keyword Dose
  • dc.title Calculating daily dose in the Observational Medical Outcomes Partnership Common Data Model
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)