Metastatic niche functions and therapeutic opportunities
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- dc.contributor.author Celià-Terrassa, Toni
- dc.contributor.author Kang, Yibin
- dc.date.accessioned 2019-06-13T06:24:12Z
- dc.date.issued 2018
- dc.description.abstract Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.
- dc.format.mimetype application/pdf
- dc.identifier.citation Celià-Terrassa T, Kang Y. Metastatic niche functions and therapeutic opportunities. Nat Cell Biol. 2018 Aug;20(8):868-877. DOI: 10.1038/s41556-018-0145-9
- dc.identifier.doi http://dx.doi.org/10.1038/s41556-018-0145-9
- dc.identifier.issn 1465-7392
- dc.identifier.uri http://hdl.handle.net/10230/41745
- dc.language.iso eng
- dc.publisher Nature Research
- dc.rights © Springer Nature Publishing AG Celià-Terrassa T, Kang Y. Metastatic niche functions and therapeutic opportunities. Nat Cell Biol. 2018 Aug;20(8):868-877. http://dx.doi.org/10.1038/s41556-018-0145-9
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other
- dc.title Metastatic niche functions and therapeutic opportunities
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion