Mammary stem cells and breast cancer stem cells: molecular connections and clinical implications

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• dc.contributor.author Celià-Terrassa, Toni
• dc.date.accessioned 2019-03-11T09:12:03Z
• dc.date.available 2019-03-11T09:12:03Z
• dc.date.issued 2018
• dc.description.abstract Cancer arises from subpopulations of transformed cells with high tumor initiation and repopulation ability, known as cancer stem cells (CSCs), which share many similarities with their normal counterparts. In the mammary gland, several studies have shown common molecular regulators between adult mammary stem cells (MaSCs) and breast cancer stem cells (bCSCs). Cell plasticity and self-renewal are essential abilities for MaSCs to maintain tissue homeostasis and regenerate the gland after pregnancy. Intriguingly, these properties are similarly executed in breast cancer stem cells to drive tumor initiation, tumor heterogeneity and recurrence after chemotherapy. In addition, both stem cell phenotypes are strongly influenced by external signals from the microenvironment, immune cells and supportive specific niches. This review focuses on the intrinsic and extrinsic connections of MaSC and bCSCs with clinical implications for breast cancer progression and their possible therapeutic applications.
• dc.format.mimetype application/pdf
• dc.identifier.citation Celià-Terrassa T. Mammary stem cells and breast cancer stem cells: molecular connections and clinical implications. Biomedicines. 2018 May 4;6(2). pii: E50. DOI: 10.3390/biomedicines6020050
• dc.identifier.doi http://dx.doi.org/10.3390/biomedicines6020050
• dc.identifier.issn 2227-9059
• dc.identifier.uri http://hdl.handle.net/10230/36788
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Biomedicines. 2018 May 4;6(2):E50
• dc.rights © Celià-Terrassa, Toni by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cancer stem cells
• dc.subject.keyword Cell plasticity
• dc.subject.keyword Immune interplay
• dc.subject.keyword Mammary stem cells
• dc.subject.keyword Targeting CSCs
• dc.subject.keyword Yumor microenvironment
• dc.title Mammary stem cells and breast cancer stem cells: molecular connections and clinical implications
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion