Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program

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• dc.contributor.author Castells, Xavier
• dc.contributor.author Domingo, Laia
• dc.contributor.author Corominas Torres, Josep Maria
• dc.contributor.author Torá Rocamora, Isabel, 1979-
• dc.contributor.author Quintana, María Jesús
• dc.contributor.author Baré, Marisa
• dc.contributor.author Vidal, Carmen
• dc.contributor.author Natal, Carmen
• dc.contributor.author Sánchez, Mar
• dc.contributor.author Saladié, Francina
• dc.contributor.author Ferrer, Joana
• dc.contributor.author Vernet, Mar
• dc.contributor.author Servitja Tormo, Sonia
• dc.contributor.author Rodríguez Arana, Ana Maria
• dc.contributor.author Román, Marta
• dc.contributor.author Espinàs, Josep Alfons
• dc.contributor.author Sala, Maria
• dc.date.accessioned 2025-01-10T07:18:38Z
• dc.date.available 2025-01-10T07:18:38Z
• dc.date.issued 2015
• dc.description.abstract Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies.
• dc.format.mimetype application/pdf
• dc.identifier.citation Castells X, Domingo L, Corominas JM, Torá-Rocamora I, Quintana MJ, Baré M, et al. Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program. Breast Cancer Res Treat. 2015 Jan;149(1):237-44. DOI: 10.1007/s10549-014-3208-z
• dc.identifier.doi http://dx.doi.org/10.1007/s10549-014-3208-z
• dc.identifier.issn 0167-6806
• dc.identifier.uri http://hdl.handle.net/10230/69038
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Breast Cancer Res Treat. 2015 Jan;149(1):237-44
• dc.rights The Author(s) 2014. This article is published with open access at Springerlink.com. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Breast cancer
• dc.subject.keyword Benign breast disease
• dc.subject.keyword Screening
• dc.subject.keyword Early detection
• dc.subject.keyword Family history
• dc.subject.keyword Risk factors
• dc.title Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion