Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts

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  • dc.contributor.author Manghi, Paolo
  • dc.contributor.author Vallès Colomer, Mireia
  • dc.contributor.author Song, Mingyang
  • dc.date.accessioned 2025-01-14T14:51:37Z
  • dc.date.available 2025-01-14T14:51:37Z
  • dc.date.issued 2024
  • dc.description.abstract Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood. Coffee is a habitually consumed beverage with established metabolic and health benefits. We previously found that coffee is, among >150 items, the food showing the highest correlation with microbiome components. Here we conducted a multi-cohort, multi-omic analysis of US and UK populations with detailed dietary information from a total of 22,867 participants, which we then integrated with public data from 211 cohorts (N = 54,198). The link between coffee consumption and microbiome was highly reproducible across different populations (area under the curve of 0.89), largely driven by the presence and abundance of the species Lawsonibacter asaccharolyticus. Using in vitro experiments, we show that coffee can stimulate growth of L. asaccharolyticus. Plasma metabolomics on 438 samples identified several metabolites enriched among coffee consumers, with quinic acid and its potential derivatives associated with coffee and L. asaccharolyticus. This study reveals a metabolic link between a specific gut microorganism and a specific food item, providing a framework for the understanding of microbial dietary responses at the biochemical level.
  • dc.description.sponsorship This work was supported by ZOE and TwinsUK, which is funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation, the National Institute for Health Research Clinical Research Network and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. We acknowledge the support of the European Research Council (ERC-STG project MetaPG-716575 and ERC-CoG microTOUCH-101045015) to N.S., of the European Union’s Horizon 2020 programme (ONCOBIOME-825410 project, MASTER-818368 project and IHMCSA-964590) to N.S., of the MUR PNRR project INEST-Interconnected Nord-Est Innovation Ecosystem (ECS00000043) funded by the NextGenerationEU to N.S., and of the National Cancer Institute of the National Institutes of Health (1U01CA230551 to N.S. and U01CA261961 and R01CA263776 to M.S.) and of the Premio Internazionale Lombardia e Ricerca 2019 to N.S. The MBS and MLVS were supported by NIH U01CA176726 and U01CA167552. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Manghi P, Bhosle A, Wang K, Marconi R, Selma-Royo M, Ricci L, et al. Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts. Nat Microbiol. 2024 Dec;9(12):3120-34. DOI: 10.1038/s41564-024-01858-9
  • dc.identifier.doi http://dx.doi.org/10.1038/s41564-024-01858-9
  • dc.identifier.issn 2058-5276
  • dc.identifier.uri http://hdl.handle.net/10230/69125
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Nat Microbiol. 2024 Dec;9(12):3120-34
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/716575
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101045015
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825410
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/818368
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/964590
  • dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Epidemiology
  • dc.subject.keyword Microbiome
  • dc.title Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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