The origins and impact of primate segmental duplications
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- dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
- dc.contributor.author Girirajan, Santhoshca
- dc.contributor.author Eichler, Evan E.ca
- dc.date.accessioned 2013-04-17T13:34:48Z
- dc.date.available 2013-04-17T13:34:48Z
- dc.date.issued 2009ca
- dc.description.abstract Duplicated sequences are substrates for the emergence of new genes and are an important source of genetic instability associated with rare and common diseases. Analyses of primate genomes have shown an increase in the proportion of interspersed segmental duplications (SDs) within the genomes of humans and great apes. This contrasts with other mammalian genomes that seem to have their recently duplicated sequences organized in a tandem configuration. In this review, we focus on the mechanistic origin and impact of this difference with respect to evolution, genetic diversity and primate phenotype. Although many genomes will be sequenced in the future, resolution of this aspect of genomic architecture still requires high quality sequences and detailed analyses.
- dc.description.sponsorship This work was supported by a Marie Curie fellowship
- dc.format.mimetype application/pdfca
- dc.identifier.citation Marques-Bonet T, Girirajan S, Eichler EE. The origins and impact of primate segmental duplications. Trends Genet. 2009;25(10):443-54. DOI: 10.1016/j.tig.2009.08.002ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.tig.2009.08.002
- dc.identifier.issn 0168-9525ca
- dc.identifier.uri http://hdl.handle.net/10230/20557
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Trends in Genetics. 2009;25(10):443-54
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/220278
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.tig.2009.08.002ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Evolució molecular
- dc.subject.other Primats -- Genètica
- dc.title The origins and impact of primate segmental duplicationsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca