Sex differences in psychiatric comorbidity and plasma biomarkers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settings

Pedraz, María; Araos, Pedro; García Marchena, Nuria; Serrano, Antonia; Romero Sanchiz, Pablo; Suárez, Juan; Castilla Ortega, Estela; Mayoral Cleries, Fermín; Ruiz, Juan Jesús; Pastor, Antonio; Barrios, Vicente; Chowen, Julie A.; Argente, Jesús; Torrens, Marta; Torre Fornell, Rafael de la; Rodríguez de Fonseca, Fernando; Pavón, Francisco Javier

Sex differences in psychiatric comorbidity and plasma biomarkers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settings

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dc.contributor.author Pedraz, Maríaca
dc.contributor.author Araos, Pedroca
dc.contributor.author García Marchena, Nuriaca
dc.contributor.author Serrano, Antoniaca
dc.contributor.author Romero Sanchiz, Pabloca
dc.contributor.author Suárez, Juanca
dc.contributor.author Castilla Ortega, Estelaca
dc.contributor.author Mayoral Cleries, Fermínca
dc.contributor.author Ruiz, Juan Jesúsca
dc.contributor.author Pastor, Antonioca
dc.contributor.author Barrios, Vicenteca
dc.contributor.author Chowen, Julie A.ca
dc.contributor.author Argente, Jesúsca
dc.contributor.author Torrens, Martaca
dc.contributor.author Torre Fornell, Rafael de laca
dc.contributor.author Rodríguez de Fonseca, Fernandoca
dc.contributor.author Pavón, Francisco Javierca
dc.date.accessioned 2015-06-11T11:42:09Z
dc.date.available 2015-06-11T11:42:09Z
dc.date.issued 2015
dc.description.abstract There are sex differences in the progression of drug addiction, relapse, and response to therapies. Because biological factors participate in these differences, they should be considered when using biomarkers for addiction. In the current study, we evaluated the sex differences in psychiatric comorbidity and the concentrations of plasma mediators that have been reported to be affected by cocaine. Fifty-five abstinent cocaine-addicted subjects diagnosed with lifetime cocaine use disorders (40 men and 15 women) and 73 healthy controls (48 men and 25 women) were clinically assessed with the diagnostic interview "Psychiatric Research Interview for Substance and Mental Disorders." Plasma concentrations of chemokines, cytokines, N-acyl-ethanolamines, and 2-acyl-glycerols were analyzed according to history of cocaine addiction and sex, controlling for covariates age and body mass index (BMI). Relationships between these concentrations and variables related to cocaine addiction were also analyzed in addicted subjects. The results showed that the concentrations of chemokine (C-C motif) ligand 2/monocyte chemotactic protein-1 (CCL2/MCP-1) and chemokine (C-X-C motif) ligand 12/stromal cell-derived factor-1 (CXCL12/SDF-1) were only affected by history of cocaine addiction. The plasma concentrations of interleukin 1-beta (IL-1β), IL-6, IL-10, and tumor necrosis factor-alpha (TNFα) were affected by history of cocaine addiction and sex. In fact, whereas cytokine concentrations were higher in control women relative to men, these concentrations were reduced in cocaine-addicted women without changes in addicted men. Regarding fatty acid derivatives, history of cocaine addiction had a main effect on the concentration of each acyl derivative, whereas N-acyl-ethanolamines were increased overall in the cocaine group, 2-acyl-glycerols were decreased. Interestingly, N-palmitoleoyl-ethanolamine (POEA) was only increased in cocaine-addicted women. The covariate BMI had a significant effect on POEA and N-arachidonoyl-ethanolamine concentrations. Regarding psychiatric comorbidity in the cocaine group, women had lower incidence rates of comorbid substance use disorders than did men. For example, alcohol use disorders were found in 80% of men and 40% of women. In contrast, the addicted women had increased prevalences of comorbid psychiatric disorders (i.e., mood, anxiety, and psychosis disorders). Additionally, cocaine-addicted subjects showed a relationship between the concentrations of N-stearoyl-ethanolamine and 2-linoleoyl-glycerol and diagnosis of psychiatric comorbidity. These results demonstrate the existence of a sex influence on plasma biomarkers for cocaine addiction and on the presence of comorbid psychopathologies for clinical purposes.ca
dc.description.sponsorship The present study has been supported by Instituto de Salud Carlos III (ISC-III), Red de Trastornos Adictivos UE-FEDER 2012 (RD12/0028); Ministerio de Economía y Competitividad (PI13/02261); Plan Nacional sobre Drogas 049/2009 and 049/2013; Consejería de Economía, Innovación y Ciencia, Junta de Andalucía UE-FEDER (CTS-433); Consejería de Salud y Bienestar Social, Junta Andalucía (PI0228-2013 and PI0823- 2012); Departament d’Innovació, Universitats i Empresa, Generalitat de Catalunya (2014-SGR-680). JS, AS, and FJP hold a “Miguel Servet” research contract from ISC-III (CP12/03109, CP14/00173, and CP14/00212, respectively). PRS holds a “Río Hortega” research contract from ISC-III (CM13/0115). ECO holds a “Sara Borrell” research contract from ISC-III (CD12/00455).
dc.format.mimetype application/pdfca
dc.identifier.citation Pedraz M, Araos P, García-Marchena N, Serrano A, Romero-Sanchiz P, Suárez J et al. Sex differences in psychiatric comorbidity and plasma biomarkers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settings. Front Psychiatry. 2015 Feb 16;6:17. DOI: 10.3389/fpsyt.2015.00017ca
dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2015.00017
dc.identifier.issn 1664-0640
dc.identifier.uri http://hdl.handle.net/10230/23790
dc.language.iso engca
dc.publisher Frontiersca
dc.relation.ispartof Frontiers in Psychiatry. 2015 Feb 16;6:17
dc.rights © 2015 Pedraz, Araos, García-Marchena, Serrano, Romero-Sanchiz,/nSuárez, Castilla-Ortega, Mayoral-Cleries, Ruiz, Pastor, Barrios, Chowen, Argente,/nTorrens, de la Torre, Rodríguez De Fonseca and Pavón. This is an open-access article/ndistributed under the terms of the Creative Commons Attribution License (CC BY).https://creativecommons.org/licenses/by/4.0//nThe use, distribution or reproduction in other forums is permitted, provided the original/nauthor(s) or licensor are credited andthatthe original publication inthis journal is cited,/nin accordance with accepted academic practice. No use, distribution or reproduction is/npermitted which does not comply with these terms.ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ca
dc.subject.other Cocaïna -- Efectes fisiològicsca
dc.subject.other Comorbiditatca
dc.subject.other Psiquiatriaca
dc.title Sex differences in psychiatric comorbidity and plasma biomarkers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settingsca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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