PFAS levels and exposure determinants in sensitive population groups

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• dc.contributor.author Fábelová, Lucia
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Palkovičová Murínová, Lubica
• dc.date.accessioned 2023-01-11T07:22:52Z
• dc.date.available 2023-01-11T07:22:52Z
• dc.date.issued 2023
• dc.description.abstract Background: Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, and consumer products that contain these chemicals. Our aim was to identify determinants of PFAS concentrations in sensitive population subgroups- pregnant women and newborns. Methods: Nine European birth cohorts provided exposure data on PFAS in pregnant women (INMA-Gipuzkoa, Sabadell, Valencia, ELFE and MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, FLEHS 3 and PRENATAL; total N = 940). PFOS, PFOA, PFHxS and PFNA concentrations were measured in maternal or cord blood, depending on the cohort (FLEHS 2 measured only PFOS and PFOA). PFAS concentrations were analysed according to maternal characteristics (age, BMI, parity, previous breastfeeding, smoking, and food consumption during pregnancy) and parental educational level. The association between potential determinants and PFAS concentrations was evaluated using multiple linear regression models. Results: We observed significant variations in PFAS concentrations among cohorts. Higher PFAS concentrations were associated with higher maternal age, primipara birth, and educational level, both for maternal blood and cord blood. Higher PFAS concentrations in maternal blood were associated with higher consumption of fish and seafood, meat, offal and eggs. In cord blood, higher PFHxS concentrations were associated with daily meat consumption and higher PFNA with offal consumption. Daily milk and dairy consumption were associated with lower concentrations of PFAS in both, pregnant women and newborns. Conclusion: High detection rates of the four most abundant PFAS demonstrate ubiquitous exposure of sensitive populations, which is of concern. This study identified several determinants of PFAS exposure in pregnant women and newborns, including dietary factors, and these findings can be used for proposing measures to reduce PFAS exposure, particularly from dietary sources.
• dc.description.sponsorship This work was supported by the European Union’s Horizon 2020 research and innovation programme under Grant agreement No 733032 HBM4EU (http://www.hbm4eu.eu), and received co-funding from the authors' organizations: 3xG: The 3xG study was financed and steered by NIRAS and the local partnerships MONA and STORA. ELFE: The Elfe survey is a joint project between the French Institute for Demographic Studies (INED) and the National Institute of Health and Medical Research (INSERM), in partnership with the French blood transfusion service (Etablissement français du sang, EFS), Santé publique France, the National Institute for Statistics and Economic Studies (INSEE), the Direction générale de la santé (DGS, part of the Ministry of Health and Social Affairs), the Direction générale de la prévention des risques (DGPR, Ministry for the Environment), the Direction de la recherche, des études, de l’évaluation et des statistiques (DREES, Ministry of Health and Social Affairs), the Département des études, de la prospective et des statistiques (DEPS, Ministry of Culture), and the Caisse nationale des allocations familiales (CNAF), with the support of the Ministry of Higher Education and Research and the Institut national de la jeunesse et de l’éducation populaire (INJEP). Via the RECONAI platform, it receives a government grant managed by the National Research Agency under the “Investissements d'avenir” programme (ANR-11-EQPX-0038 and ANR-19-COHO-0001). FLEHS: The Flemish Environment and Health studie (FLEHS) were commissioned, financed and steered by the Flemish Government (Department of Economy, Science and Innovations, Agency for Care and Health and Department of Environment). INMA Valencia: This study was funded by Grants from UE (FP7-ENV-2011 cod 282,957 and HEALTH.2010.2.4.5–1), Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663; Miguel Servet-FEDER CP11/00178, CP15/00025, and CPII16/00051), Generalitat Valenciana: FISABIO (UGP 15–230, UGP-15-244, and UGP-15-249), and Alicia Koplowitz Foundation 2017.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fábelová L, Beneito A, Casas M, Colles A, Dalsager L, Den Hond E, et al. PFAS levels and exposure determinants in sensitive population groups. Chemosphere. 2023 Feb;313:137530. DOI: 10.1016/j.chemosphere.2022.137530
• dc.identifier.doi http://dx.doi.org/10.1016/j.chemosphere.2022.137530
• dc.identifier.issn 0045-6535
• dc.identifier.uri http://hdl.handle.net/10230/55250
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Chemosphere. 2023 Feb;313:137530
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733032
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
• dc.rights © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Cord blood
• dc.subject.keyword Determinants
• dc.subject.keyword Food consumption
• dc.subject.keyword Maternal blood
• dc.subject.keyword Per- and polyfluoroalkyl substances
• dc.title PFAS levels and exposure determinants in sensitive population groups
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion