Unraveling the effect of genomic structural changes in the rhesus macaque - implications for the adaptive role of inversions

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• dc.contributor.author Ullastres, Annaca
• dc.contributor.author Farré, Martaca
• dc.contributor.author Capilla, Laiaca
• dc.contributor.author Ruiz Herrera, Auroraca
• dc.date.accessioned 2015-03-20T08:26:34Z
• dc.date.available 2015-03-20T08:26:34Z
• dc.date.issued 2014ca
• dc.description.abstract Background: By reshuffling genomes, structural genomic reorganizations provide genetic variation on which natural selection can work. Understanding the mechanisms underlying this process has been a long-standing question in evolutionary biology. In this context, our purpose in this study is to characterize the genomic regions involved in structural rearrangements between human and macaque genomes and determine their influence on meiotic recombination as a way to explore the adaptive role of genome shuffling in mammalian evolution. Results: We first constructed a highly refined map of the structural rearrangements and evolutionary breakpoint regions in the human and rhesus macaque genomes based on orthologous genes and whole-genome sequence alignments. Using two different algorithms, we refined the genomic position of known rearrangements previously reported by cytogenetic approaches and described new putative micro-rearrangements (inversions and indels) in both genomes. A detailed analysis of the rhesus macaque genome showed that evolutionary breakpoints are in gene-rich regions, being enriched in GO terms related to immune system. We also identified defense-response genes within a chromosome inversion fixed in the macaque lineage, underlying the relevance of structural genomic changes in evolutionary and/or adaptation processes. Moreover, by combining in silico and experimental approaches, we studied the recombination pattern of specific chromosomes that have suffered rearrangements between human and macaque lineages. Conclusions: Our data suggest that adaptive alleles – in this case, genes involved in the immune response – might have been favored by genome rearrangements in the macaque lineage.en
• dc.description.sponsorship This work was supported by the Ministerio de Economia y Competitividad (CGL-2010-20170)en
• dc.format.mimetype application/pdfca
• dc.identifier.citation Ullastres A, Farré M, Capilla L, Ruiz-Herrera A. Unraveling the effect of genomic structural changes in the rhesus macaque - implications for the adaptive role of inversions. BMC Genomics. 2014; 15: 530. DOI 10.1186/1471-2164-15-530ca
• dc.identifier.doi http://dx.doi.org/10.1186/1471-2164-15-530
• dc.identifier.issn 1471-2164ca
• dc.identifier.uri http://hdl.handle.net/10230/23241
• dc.language.iso engca
• dc.publisher BioMed Centralca
• dc.relation.ispartof BMC Genomics. 2014; 15: 530
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CGL2010-20170
• dc.rights © 2014 Ullastres et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0
• dc.subject.keyword Genome shufflingen
• dc.subject.keyword Inversionsen
• dc.subject.keyword Macaqueen
• dc.subject.keyword Recombinationen
• dc.subject.keyword Adaptationen
• dc.subject.keyword Meiosisen
• dc.subject.keyword Tandem repeatsen
• dc.subject.keyword Evolutionary breakpointsen
• dc.subject.other Adaptació (Biologia)ca
• dc.subject.other Cromosomes humansca
• dc.subject.other Genètica evolutivaca
• dc.title Unraveling the effect of genomic structural changes in the rhesus macaque - implications for the adaptive role of inversionsen
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca