Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers
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- dc.contributor.author Melero, Juan L.
- dc.contributor.author Lidón-Moyano, Cristina
- dc.contributor.author Pérez Ortuño, Raúl, 1976-
- dc.contributor.author Fu, Marcela
- dc.contributor.author Ballbé, Montse
- dc.contributor.author Martín-Sánchez, Juan Carlos
- dc.contributor.author González-Marrón, Adrián
- dc.contributor.author Cartanyà-Hueso, Àurea
- dc.contributor.author Pascual Esteban, José A.
- dc.contributor.author Fernández, Esteve
- dc.contributor.author Martínez-Sánchez, Jose M.
- dc.date.accessioned 2024-05-08T08:20:48Z
- dc.date.available 2024-05-08T08:20:48Z
- dc.date.embargoEnd info:eu-repo/date/embargoEnd/2025-01-08
- dc.date.issued 2023
- dc.description.abstract Introduction: This study aims to address the existing gap in the literature, while adding evidence, by comparing tobacco-specific biomarkers (cotinine and nitrosamines: NNK, NNAL, NNN), and other biomarkers of e-cigarette use (humectants: glycerol, 1,2-PD, 1,3-PD) according to five study groups. Methods: A pooling analysis including two different studies was conducted. In both analyses, we took saliva samples from smokers (n = 409) and non-smokers (n = 154), dual tobacco and e-cig users (n = 92), exclusive e-cig user with nicotine (n = 158), and exclusive e-cig users without nicotine (n = 38). We analyzed and compared the geometric means (GM) and geometric standard deviations (GSD) of the concentration of tobacco-specific biomarkers, and e-cigarette biomarkers among groups. We used log-linear models adjusted for sex and age to model the change percentage and their 95% confidence intervals. Results: Cotinine was significantly higher in nicotine consumers and in e-cigarette users without nicotine when compared to non-smokers. TSNAs were generally significantly lower in non-smokers and higher in nicotine consumers. NNN and NNAL were lower in e-cigarette users with nicotine comparted to smokers, and NNN was higher in e-cigarette users without nicotine when compared to non-smokers. No differences were found in humectant biomarkers between e-cigarette groups. Conclusions: Although there was a reduction in TSNAs in e-cigarette exclusive users compared to smokers, and a reduction of cotinine concentrations in e-cigarette exclusive users without nicotine compared to smokers, there are still high levels of these biomarkers when compared to non-smokers, which may be a clue towards the harmful effect of e-cigarettes.
- dc.embargo.liftdate 2025-01-08
- dc.format.mimetype application/pdf
- dc.identifier.citation Melero-Ollonarte JL, Lidón-Moyano C, Perez-Ortuño R, Fu M, Ballbè M, Martín-Sánchez JC, et al. Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers. Addict Behav. 2023 May;140:107616. DOI: 10.1016/j.addbeh.2023.107616
- dc.identifier.doi http://dx.doi.org/10.1016/j.addbeh.2023.107616
- dc.identifier.issn 0306-4603
- dc.identifier.uri http://hdl.handle.net/10230/60078
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Addict Behav. 2023 May;140:107616
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.addbeh.2023.107616
- dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
- dc.subject.keyword Biomarker
- dc.subject.keyword Cotinine
- dc.subject.keyword E-cigarette
- dc.subject.keyword Glycerol
- dc.subject.keyword Propanediols
- dc.subject.keyword TSNAs
- dc.subject.keyword Tobacco
- dc.title Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion