Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty

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• dc.contributor.author Pusceddu, Claudio
• dc.contributor.author Marsico, Salvatore
• dc.contributor.author Derudas, Daniele
• dc.contributor.author Ballicu, Nicola
• dc.contributor.author Melis, Luca
• dc.contributor.author Zedda, Stefano
• dc.contributor.author De Felice, Carlo
• dc.contributor.author Calabrese, Alessandro
• dc.contributor.author De Francesco, Davide
• dc.contributor.author Venturini, Massimo
• dc.contributor.author Santucci, Domiziana
• dc.contributor.author Faiella, Eliodoro
• dc.date.accessioned 2024-05-21T06:24:22Z
• dc.date.available 2024-05-21T06:24:22Z
• dc.date.issued 2023
• dc.description.abstract (1) Background: to retrospectively evaluate safety and efficacy of combined microwave ablation (MWA) and bilateral expandable titanium SpineJack (SJ) implants followed by vertebroplasty (VP) for the treatment of painful thoracolumbar pathological vertebral compression fracture. (2) Methods: from July 2017 to October 2022, twenty-eight patients (13 women and 15 men; mean age 68 ± 11 years) with a history of primary neoplasm and thirty-six painful vertebral metastases with vertebral compression fracture underwent combined MWA and bilateral expandable titanium SpineJack implants with vertebroplasty. We analyzed safety through complications rate, and efficacy through vertebral height restoration and pain decrease, evaluated using a visual analogue scale (VAS), and Functional Mobility Scale (FMS), and local tumor control. Contrast-enhanced CT scans were performed at 1, 3, and 6 months and a contrast-enhanced spine MRI at 6 months after the procedure. (3) Results: Technical success rate was 100%. No procedure-related major complications or death occurred. Vertebral height restoration was observed in 22 levels (58%), with a mean anterior height restoration of 2.6 mm ± 0.6 and a mean middle height restoration of 4.4 mm ± 0.6 (p < 0.001). Mean VAS score of pain evaluation on the day before treatment was 6.3 ± 1.5 (range 4-9). At the 6-month evaluation, the median VAS score for pain was 0.4 ± 0.6 (range 0-2) with a mean reduction of 93.65% (6.8 ± 0.7 vs. 0.4 ± 0.6; p < 0.000) compared with baseline evaluation. Contrast-enhanced CT scans were performed at 1, 3, and 6 months and a contrast-enhanced spine MRI was performed at 6 months after the procedure, showing no local recurrence, implant displacement, or new fractures in the treated site. (4) Conclusions: combined microwave ablation and bilateral expandable titanium SpineJack implants with vertebroplasty is a safe and effective procedure for the treatment of pathological compressive vertebral fractures. The vertebral stabilization achieved early and persistent pain relief, increasing patient mobility, improving recovery of walking capacity, and providing local tumor control.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pusceddu C, Marsico S, Derudas D, Ballicu N, Melis L, Zedda S, et al. Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty. J Clin Med. 2023 Jun 21;12(13):4178. DOI: 10.3390/jcm12134178
• dc.identifier.doi http://dx.doi.org/10.3390/jcm12134178
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/60197
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Clin Med. 2023 Jun 21;12(13):4178
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Expandable titanium SpineJack implants
• dc.subject.keyword Interventional radiology
• dc.subject.keyword Microwave ablation
• dc.subject.keyword Percutaneous therapies
• dc.subject.keyword Spine metastases
• dc.title Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion