Household severe acute respiratory syndrome coronavirus 2 transmission and children: a network prospective study

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• dc.contributor.author Soriano-Arandes, Antoni
• dc.contributor.author López Segura, María Nuria
• dc.contributor.author Soler-Palacín, Pere
• dc.contributor.author COVID-19 Pediatric Disease in Catalonia Research Group
• dc.date.accessioned 2022-05-27T06:27:25Z
• dc.date.issued 2021
• dc.description.abstract Background: The role of children in household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. We describe the epidemiological and clinical characteristics of children with coronavirus disease 2019 (COVID-19) in Catalonia, Spain, and investigate the household transmission dynamics. Methods: A prospective, observational, multicenter study was performed during summer and school periods (1 July 2020-31 October 2020) to analyze epidemiological and clinical features and viral household transmission dynamics in COVID-19 patients aged <16 years. A pediatric index case was established when a child was the first individual infected. Secondary cases were defined when another household member tested positive for SARS-CoV-2 before the child. The secondary attack rate (SAR) was calculated, and logistic regression was used to assess associations between transmission risk factors and SARS-CoV-2 infection. Results: The study included 1040 COVID-19 patients. Almost half (47.2%) were asymptomatic, 10.8% had comorbidities, and 2.6% required hospitalization. No deaths were reported. Viral transmission was common among household members (62.3%). More than 70% (756/1040) of pediatric cases were secondary to an adult, whereas 7.7% (80/1040) were index cases. The SAR was significantly lower in households with COVID-19 pediatric index cases during the school period relative to summer (P = .02) and compared to adults (P = .006). No individual or environmental risk factors associated with the SAR. Conclusions: Children are unlikely to cause household COVID-19 clusters or be major drivers of the pandemic, even if attending school. Interventions aimed at children are expected to have a small impact on reducing SARS-CoV-2 transmission.
• dc.format.mimetype application/pdf
• dc.identifier.citation Soriano-Arandes A, Gatell A, Serrano P, Biosca M, Campillo F, Capdevila R, et al. Household severe acute respiratory syndrome coronavirus 2 transmission and children: a network prospective study. Clin Infect Dis. 2021 Sep 15; 73(6): e1261-69. DOI: 10.1093/cid/ciab228
• dc.identifier.doi http://dx.doi.org/10.1093/cid/ciab228
• dc.identifier.issn 1058-4838
• dc.identifier.uri http://hdl.handle.net/10230/53285
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical infectious diseases following peer review. The version of record Soriano-Arandes A, Gatell A, Serrano P, Biosca M, Campillo F, Capdevila R, et al. Household severe acute respiratory syndrome coronavirus 2 transmission and children: a network prospective study. Clin Infect Dis. 2021 Sep 15; 73(6): e1261-69, is available online at: https://academic.oup.com/cid/article/73/6/e1261/6168547?login=false
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword SARS-CoV-2
• dc.subject.keyword Child
• dc.subject.keyword Coronavirus
• dc.subject.keyword Household
• dc.subject.keyword Transmission
• dc.title Household severe acute respiratory syndrome coronavirus 2 transmission and children: a network prospective study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion