Etiology and diagnosis of permanent hypoparathyroidism after total thyroidectomy

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• dc.contributor.author Sitges-Serra, Antonio
• dc.date.accessioned 2022-06-21T06:48:55Z
• dc.date.available 2022-06-21T06:48:55Z
• dc.date.issued 2021
• dc.description.abstract Postoperative parathyroid failure is the commonest adverse effect of total thyroidectomy, which is a widely used surgical procedure to treat both benign and malignant thyroid disorders. The present review focuses on the scientific gap and lack of data regarding the time period elapsed between the immediate postoperative period, when hypocalcemia is usually detected by the surgeon, and permanent hypoparathyroidism often seen by an endocrinologist months or years later. Parathyroid failure after thyroidectomy results from a combination of trauma, devascularization, inadvertent resection, and/or autotransplantation, all resulting in an early drop of iPTH (intact parathyroid hormone) requiring replacement therapy with calcium and calcitriol. There is very little or no role for other factors such as vitamin D deficiency, calcitonin, or magnesium. Recovery of the parathyroid function is a dynamic process evolving over months and cannot be predicted on the basis of early serum calcium and iPTH measurements; it depends on the number of parathyroid glands remaining in situ (PGRIS)-not autotransplanted nor inadvertently excised-and on early administration of full-dose replacement therapy to avoid hypocalcemia during the first days/weeks after thyroidectomy.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sitges-Serra A. Etiology and diagnosis of permanent hypoparathyroidism after total thyroidectomy. J Clin Med. 2021 Feb 2; 10(3): 543. DOI: 10.3390/jcm10030543
• dc.identifier.doi http://dx.doi.org/10.3390/jcm10030543
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/53548
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright: © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http:// creativecommons.org/licenses/by/ 4.0/
• dc.subject.keyword PGRIS
• dc.subject.keyword Hypoparathyroidism
• dc.subject.keyword Parathyroid failure
• dc.subject.keyword Recovery
• dc.subject.keyword Splinting
• dc.subject.keyword Thyroidectomy
• dc.title Etiology and diagnosis of permanent hypoparathyroidism after total thyroidectomy
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion