Association between oxidative potential of particulate matter collected by personal samplers and systemic inflammation among asthmatic and non-asthmatic adults

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  • dc.contributor.author Santibáñez, Miguel
  • dc.contributor.author Ruiz-Cubillán, Juan José
  • dc.contributor.author Expósito, Andrea
  • dc.contributor.author Agüero, Juan
  • dc.contributor.author García-Rivero, Juan Luis
  • dc.contributor.author Abascal, Beatriz
  • dc.contributor.author Amado, Carlos Antonio
  • dc.contributor.author Ruiz-Azcona, Laura
  • dc.contributor.author López-Hoyos, Marcos
  • dc.contributor.author Irure, Juan
  • dc.contributor.author Robles, Yolanda
  • dc.contributor.author Berja, Ana
  • dc.contributor.author Barreiro Portela, Esther
  • dc.contributor.author Núñez-Robainas, Adriana
  • dc.contributor.author Cifrián, José Manuel
  • dc.contributor.author Fernandez-Olmo, Ignacio
  • dc.date.accessioned 2025-03-26T07:32:26Z
  • dc.date.available 2025-03-26T07:32:26Z
  • dc.date.issued 2024
  • dc.description.abstract With the rationale that the oxidative potential of particulate matter (PM-OP) may induce oxidative stress and inflammation, we conducted the ASTHMA-FENOP study in which 44 asthmatic patients and 37 matched controls wore a personal sampler for 24 h, allowing the collection of fine and coarse PM fractions separately, to determine PM-OP by the dithiothreitol (DTT) and ascorbic acid (AA) methods. The levels of Interleukin 6 (IL-6) and the IL-6/IL-10 ratio, as indicators of pro- and anti-inflammatory statuses, were determined by calculating the mean differences (MDs), odds ratios (ORs) and p-trends adjusted for sex, age, study level and body mass index. Positive associations for IL-6 levels in the form of adjusted MDs and ORs were obtained for all PM-OP metrics, reaching statistical significance for both OP-DTT and OP-AA in the fine fraction, with adjusted OR = 5.66; 95%CI (1.46 to 21.92) and 3.32; 95%CI (1.07 to 10.35), respectively, along with statistically significant dose-response patterns when restricting to asthma and adjusted also for clinical variables (adjusted p-trend = 0.029 and 0.01). Similar or stronger associations and dose-response patterns were found for the IL-6/IL-10 ratio. In conclusion, our findings on the effect of PM-OP on systemic inflammation support that asthma is a heterogeneous disease at the molecular level, with PM-OP potentially playing an important role.
  • dc.description.sponsorship This work was supported by the Spanish Society of Pneumology (SEPAR Nº 1383/23; Nº 1616/24) and the Spanish Ministry of Science and Innovation (Project PID2020-114787RBI00, funded by MCIN/AEI/10.13039/501100011033 and “ERDF A way of making Europe”).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Santibáñez M, Ruiz-Cubillán JJ, Expósito A, Agüero J, García-Rivero JL, Abascal B, et al. Association between oxidative potential of particulate matter collected by personal samplers and systemic inflammation among asthmatic and non-asthmatic adults. Antioxidants (Basel). 2024 Nov 28;13(12):1464. DOI: 10.3390/antiox13121464
  • dc.identifier.doi http://dx.doi.org/10.3390/antiox13121464
  • dc.identifier.issn 2076-3921
  • dc.identifier.uri http://hdl.handle.net/10230/70014
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Antioxidants (Basel). 2024 Nov 28;13(12):1464
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114787RBI00
  • dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Asthma
  • dc.subject.keyword Interleukin-6
  • dc.subject.keyword Oxidative potential (OP)
  • dc.subject.keyword Particulate matter (PM)
  • dc.subject.keyword Systemic inflammation
  • dc.title Association between oxidative potential of particulate matter collected by personal samplers and systemic inflammation among asthmatic and non-asthmatic adults
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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