Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata
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- dc.contributor.author Boattini, Alessioca
- dc.contributor.author Martínez Cruz, Begoñaca
- dc.contributor.author Sarno, Stefaniaca
- dc.contributor.author Harmant, Christineca
- dc.contributor.author Useli, Antonellaca
- dc.contributor.author Sanz, Paulaca
- dc.contributor.author Yang-Yao, Danieleca
- dc.contributor.author Manry, Jeremyca
- dc.contributor.author Ciani, Graziellaca
- dc.contributor.author Luiselli, Donataca
- dc.contributor.author Quintana Murci, Lluisca
- dc.contributor.author Comas, David, 1969-ca
- dc.contributor.author Pettener, Davideca
- dc.contributor.author Genographic Consortiumca
- dc.date.accessioned 2015-05-13T08:08:22Z
- dc.date.available 2015-05-13T08:08:22Z
- dc.date.issued 2013ca
- dc.description.abstract Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural and demic strata) has shaped the pattern of the modern Italian genetic structure. With the aim of disentangling this pattern and understanding which processes more importantly shaped the distribution of diversity, we have analyzed the uniparentally-inherited markers in 900 individuals from an extensive sampling across the Italian peninsula, Sardinia and Sicily. Spatial PCAs and DAPCs revealed a sex-biased pattern indicating different demographic histories for males and females. Besides the genetic outlier position of Sardinians, a North West–South East Y-chromosome structure is found in continental Italy. Such structure is in agreement with recent archeological syntheses indicating two independent and parallel processes of Neolithisation. In addition, date estimates pinpoint the importance of the cultural and demographic events during the late Neolithic and Metal Ages. On the other hand, mitochondrial diversity is distributed more homogeneously in agreement with older population events that might be related to the presence of an Italian Refugium during the last glacial period in Europeen
- dc.description.sponsorship This study was supported by Strategic Project 2006-09 from the University of Bologna to DP and from MIUR PRIN 2007 and 2009 Grants to DP. The project was also supported by the Spanish Government grant CGL2010-14944/BOSen
- dc.format.mimetype application/pdfca
- dc.identifier.citation MartÍnez-Cruz B, Sarno S, Harmant C, Useli A, Sanz P, Yang-YaoD et al. Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata. PLoS ONE. 2013;8(5):e65441. DOI: 10.1371/journal.pone.0065441ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0065441
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23569
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2013;8(5):e65441
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CGL2010-14944
- dc.rights © 2013 Boattini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.other ADN mitocondrial -- Genèticaca
- dc.subject.other Cromosoma Yca
- dc.title Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strataen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca