Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study

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  • dc.contributor.author Koch, Sarah
  • dc.contributor.author Prado Peralta, María Gabriela
  • dc.contributor.author Carsin, Anne-Elie
  • dc.contributor.author Abellan, Alicia
  • dc.contributor.author Roda, Célina
  • dc.contributor.author Torrent, Maties
  • dc.contributor.author Iñiguez, Carmen
  • dc.contributor.author Ballester Díez, Ferran
  • dc.contributor.author Ferrero, Amparo
  • dc.contributor.author Zabaleta, Carlos
  • dc.contributor.author Lertxundi, Aitana
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author Vrijheid, Martine
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Casas Sanahuja, Maribel
  • dc.contributor.author García Aymerich, Judith
  • dc.date.accessioned 2024-09-03T12:59:08Z
  • dc.date.available 2024-09-03T12:59:08Z
  • dc.date.issued 2024
  • dc.description.abstract Objective: The existence of catch-up lung function growth and its predictors is uncertain. We aimed to identify lung function trajectories and their predictors in a population-based birth cohort. Methods: We applied group-based trajectory modelling to z-scores of forced expiratory volume in 1 second (zFEV1) and z-scores of forced vital capacity (zFVC) from 1151 children assessed at around 4, 7, 9, 10, 11, 14 and 18 years. Multinomial logistic regression models were used to test whether potential prenatal and postnatal predictors were associated with lung function trajectories. Results: We identified four lung function trajectories: a low (19% and 19% of the sample for zFEV1 and zFVC, respectively), normal (62% and 63%), and high trajectory (16% and 13%) running in parallel, and a catch-up trajectory (2% and 5%) with catch-up occurring between 4 and 10 years. Fewer child allergic diseases and higher body mass index z-score (zBMI) at 4 years were associated with the high and normal compared with the low trajectories, both for zFEV1 and zFVC. Increased children's physical activity during early childhood and higher zBMI at 4 years were associated with the catch-up compared with the low zFEV1 trajectory (relative risk ratios: 1.59 per physical activity category (1.03-2.46) and 1.47 per zBMI (0.97-2.23), respectively). No predictors were identified for zFVC catch-up growth. Conclusion: We found three parallel-running and one catch-up zFEV1 and zFVC trajectories, and identified physical activity and body mass at 4 years as predictors of zFEV1 but not zFVC catch-up growth.
  • dc.description.sponsorship This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI17/01194 incl. FEDER funds; PI17/01340 incl. FEDER funds; PI18/00547 incl. FEDER funds; PI20/01695 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21; EST-19 RF-04; 2019/1/233), EU Commission (261357, 308333, 603794; 634453; 825712 and 874583). Valencia: This study was funded by Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Spain: ISCIII (G03/176; FIS-FEDER: PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663; Miguel Servet-FEDER CP11/00178, CP15/00025, and MSII16/00051), Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), and Alicia Koplowitz Foundation 2017. Menorca: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; 97/0588; 00/0021-2; PI061756; PS0901958; PI14/00677 incl. FEDER funds), CIBERESP, Beca de la IV convocatoria de Ayudas a la Investigación en Enfermedades Neurodegenerativas de La Caixa, and EC Contract No. QLK4-CT-2000-00263. Funding of authors and institution: Sarah Koch was funded by a Marie Sklodowska Curie Individual Fellowship by the European Commission (80513); Célina Roda was the recipient of a European Respiratory Society Fellowship (RESPIRE3-2E01703-00127), under H2020 - Marie Skłodowska-Curie actions COFUND; Maribel Casas and Mònica Guxens received funding from the Instituto de Salud Carlos III Miguel Servet Fellowship (MS16/00128 and CPII18/00018). The Barcelona Institute for Global Health (ISGlobal) receives support from the Spanish Ministry of Science, Innovation and Universities through the 'Centro de Excelencia Severo Ochoa 2019–2023' Programme (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Programme.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Koch S, Peralta GP, Carsin AE, Abellan A, Roda C, Torrent M, et al. Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study. Thorax. 2024 Jul 16;79(8):762-69. DOI: 10.1136/thorax-2022-219666
  • dc.identifier.doi http://dx.doi.org/10.1136/thorax-2022-219666
  • dc.identifier.issn 0040-6376
  • dc.identifier.uri http://hdl.handle.net/10230/60992
  • dc.language.iso eng
  • dc.publisher BMJ Publishing Group
  • dc.relation.ispartof Thorax. 2024 Jul 16;79(8):762-69
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825712
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.rights © Author(s). Published by BMJ Publishing Group http://dx.doi.org/10.1136/thorax-2022-219666. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword COPD epidemiology
  • dc.subject.keyword Exercise
  • dc.title Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)