Contribution of Human papillomavirus in neuroendocrine tumors from a series of 10,575 invasive cervical cancer cases

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• dc.contributor.author Alejo, Maríaca
• dc.contributor.author Alemany, Laiaca
• dc.contributor.author Clavero, Omarca
• dc.contributor.author Quirós, Beatrizca
• dc.contributor.author Vighi, Susana Gracielaca
• dc.contributor.author Seoud, Muhieddineca
• dc.contributor.author Cheng-Yang, Chouca
• dc.contributor.author Garland, Suzanne Marieca
• dc.contributor.author Juanpere, Nuriaca
• dc.contributor.author Lloreta, Josep, 1958-ca
• dc.contributor.author Tous, Saraca
• dc.contributor.author Klaustermeier, Jo Ellenca
• dc.contributor.author Quint, Wimca
• dc.contributor.author Bosch José, Francesc Xavier, 1947-ca
• dc.contributor.author Sanjosé Llongueras, Silvia deca
• dc.contributor.author Lloveras Rubio, Belenca
• dc.contributor.author RIS Human papillomavirus (HPV) TT study groupca
• dc.date.accessioned 2018-05-09T09:39:41Z
• dc.date.available 2018-05-09T09:39:41Z
• dc.date.issued 2018
• dc.description.abstract AIMS: Neuroendocrine tumors (NET) of the cervix are rare tumors with a very aggressive course. The human papillomavirus (HPV) has been linked to its etiology. The objective of this study is to describe HPV prevalence and genotype distribution of NET. METHODS AND RESULTS: Forty-nine tumors with histological neuroendocrine features were identified among 10,575 invasive cervical cancer (ICC) cases from an international study. HPV DNA detection was done using SPF10/DEIA /LiPA25 system. Immunohistochemical (IHC) staining for neuroendocrine markers (chromogranin A, synaptophysin, CD56) and for p16INK4a as a surrogate for HPV transforming infection was performed. In 13 samples with negative IHC for all 3 neuroendocrine markers studied, it was possible to conduct electron microscopy (EM). NET represented 0.5% of the total ICC series and HPV was detected in 42 out of 49 samples (85.7%, 95%CI:72.8%,94.1%). HPV16 was the predominant type (54.8%), followed by HPV18 (40.5%). p16INK4a overexpression was observed in 38/44 cases (86.4%). Neuroendocrine IHC markers could be demonstrated in 24/37 (64.9%) cases. EM identified neuroendocrine granules in 8 samples with negative IHC markers. CONCLUSIONS: Our data confirms the association of cervical NET with HPV and p16INK4a overexpression. Specifically, HPV16 and 18 accounted together for over 95% of the HPV positive cases. Current HPV vaccines could largely prevent these aggressive tumors.
• dc.format.mimetype application/pdf
• dc.identifier.citation Alejo M, Alemany L, Clavero O, Quiros B, Vighi S, Seoud M et al. RIS HPV TT study group. Contribution of Human papillomavirus in neuroendocrine tumors from a series of 10,575 invasive cervical cancer cases. Papillomavirus Research 2018 June; 5: 134-142. DOI: 10.1016/j.pvr.2018.03.005
• dc.identifier.doi http://dx.doi.org/10.1016/j.pvr.2018.03.005
• dc.identifier.issn 2405-8521
• dc.identifier.uri http://hdl.handle.net/10230/34595
• dc.language.iso eng
• dc.publisher Elsevierca
• dc.relation.ispartof Papillomavirus Research 2018 June; 5: 134-142
• dc.rights © 2018 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Cervical cancer
• dc.subject.keyword Human papillomavirus
• dc.subject.keyword Immunohistochemistry
• dc.subject.keyword Neuroendocrine tumor
• dc.subject.keyword PCR
• dc.title Contribution of Human papillomavirus in neuroendocrine tumors from a series of 10,575 invasive cervical cancer casesca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion