American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort

Díaz-Gutiérrez, Jesús; Martínez-González, Miguel Ángel, 1957-; Alonso, Alvaro; Toledo, Estefania; Salas Salvadó, Jordi; Sorlí, José Vicente; Ros, Emilio; Fitó Colomer, Montserrat; Estruch, Ramón; Arós, Fernando; Fiol, Miquel; Lapetra, José; Gómez-Gracia, Enrique; Serra Majem, Lluís; Pintó Sala, Xavier; Portolés, Olga; Babio, Nancy; Castañer, Olga; Ruiz-Canela, Miguel

American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort

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dc.contributor.author Díaz-Gutiérrez, Jesús
dc.contributor.author Martínez-González, Miguel Ángel, 1957-
dc.contributor.author Alonso, Alvaro
dc.contributor.author Toledo, Estefania
dc.contributor.author Salas Salvadó, Jordi
dc.contributor.author Sorlí, José Vicente
dc.contributor.author Ros, Emilio
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Estruch, Ramón
dc.contributor.author Arós, Fernando
dc.contributor.author Fiol, Miquel
dc.contributor.author Lapetra, José
dc.contributor.author Gómez-Gracia, Enrique
dc.contributor.author Serra Majem, Lluís
dc.contributor.author Pintó Sala, Xavier
dc.contributor.author Portolés, Olga
dc.contributor.author Babio, Nancy
dc.contributor.author Castañer, Olga
dc.contributor.author Ruiz-Canela, Miguel
dc.date.accessioned 2024-04-09T06:27:12Z
dc.date.available 2024-04-09T06:27:12Z
dc.date.issued 2023
dc.description.abstract Background and aims: The American Heart Association proposed 7 ideal cardiovascular health metrics (Life's Simple 7 [LS7]) namely, not smoking, body mass index <25 kg/m2, healthy diet, moderate physical activity ≥150 min/week, total blood cholesterol <200 mg/dL, blood pressure <120/80 mmHg and fasting blood glucose <100 mg/dL. Our objective was to assess the association between these LS7 metrics and the incidence of atrial fibrillation (AF). Methods and results: A total of 6,479 participants of the PREDIMED study were included. We calculated the participants' baseline LS7 index ranging 0-7 points to categorize them according to their adherence to these LS7 health metrics. Multivariable Cox regression models were used to estimate Hazard Ratios (HR) and their 95% Confidence Intervals (95% CI). After a median follow-up of 4.8 years, we identified 250 incident cases of AF. After adjusting for potential confounders, adherence to LS7 index was not associated with the incidence of AF (adjusted HR 0.90 [95% CI: 0.56-1.45] for highest vs. lowest LS7 categories). Body mass index <25 kg/m2 was the only health metric individually associated with a lower risk of AF (HR 0.36 [95% CI: 0.16-0.78]). Conclusions: In a high cardiovascular risk Spanish population, adherence to American Heart Association's LS7 metrics was not associated with the risk of incident AF. Clinical trials number: ISRCTN35739639.
dc.description.sponsorship PREDIMED trial was supported by the official funding agency for biomedical research of the Spanish government (Instituto de Salud Carlos III) RTIC G03/140 (Coordinator: Dr Estruch) and RTIC RD 06/0045 (Coordinator: Dr Martínez-González). We also acknowledge grants from the National Institutes of Health, United States (1R01HL118264-01); Fondo de Investigación Sanitaria - Fondo Europeo de Desarrollo Regional (PI04/0233, PI05/0976, PI07/0240, PI10/01407, PI10/02658, PI11/00049, PI11/02505 and AGL2010-22319-C03-03); Consejería de Salud de la Junta de Andalucía (PI0105/2007), and by the Generalitat Valenciana, Spain (ACOMP/2013/165 and ACOMP/2013/159).
dc.format.mimetype application/pdf
dc.identifier.citation Díaz-Gutiérrez J, Martínez-González MÁ, Alonso A, Toledo E, Salas-Salvadó J, Sorlí JV, et al. American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort. Nutr Metab Cardiovasc Dis. 2023 Jun;33(6):1144-8. DOI: 10.1016/j.numecd.2023.02.004
dc.identifier.doi http://dx.doi.org/10.1016/j.numecd.2023.02.004
dc.identifier.issn 0939-4753
dc.identifier.uri http://hdl.handle.net/10230/59694
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Nutr Metab Cardiovasc Dis. 2023 Jun;33(6):1144-8
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03-03
dc.rights © 2023 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Atrial fibrillation
dc.subject.keyword Cardiovascular disease prevention
dc.subject.keyword Cardiovascular health
dc.subject.keyword Life simple 7
dc.subject.keyword Lifestyle
dc.subject.keyword PREDIMED
dc.title American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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