Major histocompatibility complex variation and haplotype associated survival in response to experimental infection of two Bd-GPL strains along a latitudinal gradient

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• dc.contributor.author Cortázar-Chinarro, Maria
• dc.contributor.author Meurling, Sara
• dc.contributor.author Schroyens, Laurens
• dc.contributor.author Siljestam, Mattias
• dc.contributor.author Richter-Boix, Alex
• dc.contributor.author Laurila, Anssi
• dc.contributor.author Höglund, Jacob
• dc.date.accessioned 2024-05-06T05:37:28Z
• dc.date.available 2024-05-06T05:37:28Z
• dc.date.issued 2022
• dc.description.abstract While both innate and adaptive immune system mechanisms have been implicated in resistance against the chytrid fungus Batrachochytrium dendrobatidis (Bd), studies on the role of specific MHC haplotypes on Bd infection are rare. Here, we studied variation in MHC Class IIB loci in the common toad Bufo bufo along a latitudinal gradient across Sweden. In general, Swedish toad populations had few MHC Class IIB haplotypes and MHC diversity declined from south (13 haplotypes) to the north (four haplotypes). The low diversity may compromise the ability of northern populations to fight emerging disease, such as Bd. In a laboratory experiment, we infected newly metamorphosed toads with two strains of the Global Pandemic Lineage of the fungus (Bd-GPL) and compared survival with sham controls. Bd-infected toads had lower survival compared to controls. Moreover, survival was dependent on the Bd-strain and northern toads had lower Bd-mediated survival than southern individuals. MHC diversity was lower in northern toads. All northern experimental animals were monomorphic for a single MHC haplotype, whereas we found seven different haplotypes in southern experimental animals. In southern toads, survival was dependent on both Bd-strain and MHC haplotype suggesting differential infection dynamics depending on both Bd-strain and host immune system characteristics.
• dc.format.mimetype application/pdf
• dc.identifier.citation Cortázar-Chinarro M, Meurling S, Schroyens L, Siljestam M, Richter-Boix A, Laurila A, et al. Major histocompatibility complex variation and haplotype associated survival in response to experimental infection of two Bd-GPL strains along a latitudinal gradient. Front Ecol Evol. 2022 Jul 4;10:915271. DOI: 10.3389/fevo.2022.915271
• dc.identifier.doi http://dx.doi.org/10.3389/fevo.2022.915271
• dc.identifier.issn 2296-701X
• dc.identifier.uri http://hdl.handle.net/10230/60004
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in ecology and evolution. 2022 Jul 4;10:915271
• dc.rights © 2022 Cortazar-Chinarro, Meurling, Schroyens, Siljestam, Richter-Boix, Laurila and Höglund. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword MHC
• dc.subject.keyword Infection
• dc.subject.keyword Disease
• dc.subject.keyword Amphibian
• dc.subject.keyword Chytrid fungus
• dc.subject.keyword Bufo bufo
• dc.title Major histocompatibility complex variation and haplotype associated survival in response to experimental infection of two Bd-GPL strains along a latitudinal gradient
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion