Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
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- dc.contributor.author Rufus-Membere, Pamela
- dc.contributor.author Holloway-Kew, Kara L.
- dc.contributor.author Diez-Perez, Adolfo
- dc.contributor.author Appelman-Dijkstra, Natasha M.
- dc.contributor.author Bouxsein, Mary L.
- dc.contributor.author Eriksen, Erik Fink
- dc.contributor.author Farr, Joshua N.
- dc.contributor.author Khosla, Sundeep
- dc.contributor.author Kotowicz, Mark A.
- dc.contributor.author Nogués Solan, Francesc Xavier
- dc.contributor.author Rubin, Mishaela
- dc.contributor.author Pasco, Julie A.
- dc.date.accessioned 2023-05-23T06:04:42Z
- dc.date.available 2023-05-23T06:04:42Z
- dc.date.issued 2023
- dc.description.abstract Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical bone that is then indexed to the depth of the tip into a reference material. The aim of this study was to define the reference intervals for men and women by evaluating healthy adults from the United States of America, Europe and Australia. Participants included community-based volunteers and participants drawn from clinical and population-based studies. BMSi was measured on the tibial diaphysis using an OsteoProbe in 479 healthy adults (197 male and 282 female, ages 25 to 98 years) across seven research centres, between 2011 and 2018. Associations between BMSi, age, sex and areal bone mineral density (BMD) were examined following an a posteriori method. Unitless BMSi values ranged from 48 to 101. The mean (± standard deviation) BMSi for men was 84.4 ± 6.9 and for women, 79.0 ± 9.1. Healthy reference intervals for BMSi were identified as 71.0 to 97.9 for men and 59.8 to 95.2 for women. This study provides healthy reference data that can be used to calculate T- and Z-scores for BMSi and assist in determining the utility of BMSi in fracture prediction. These data will be useful for positioning individuals within the population and for identifying those with BMSi at the extremes of the population.
- dc.format.mimetype application/pdf
- dc.identifier.citation Rufus-Membere P, Holloway-Kew KL, Diez-Perez A, Appelman-Dijkstra NM, Bouxsein ML, Eriksen EF, et al. Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study. Calcif Tissue Int. 2023 Mar;112(3):338-49. DOI: 10.1007/s00223-022-01047-y
- dc.identifier.doi http://dx.doi.org/10.1007/s00223-022-01047-y
- dc.identifier.issn 1432-0827
- dc.identifier.uri http://hdl.handle.net/10230/56926
- dc.language.iso eng
- dc.publisher Springer
- dc.relation.ispartof Calcified Tissue International. 2023 Mar;112(3):338-49
- dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Impact microindentation
- dc.subject.keyword Reference interval
- dc.subject.keyword Osteoporosis
- dc.subject.keyword Bone material strength index
- dc.subject.keyword Normative data
- dc.title Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion