Living on the edge: stress and activation of stress responses promote lifespan extension
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- dc.contributor.author Zuin, Alice, 1978-ca
- dc.contributor.author Castellano Esteve, Davidca
- dc.contributor.author Ayté del Olmo, Joséca
- dc.contributor.author Hidalgo Hernando, Elenaca
- dc.date.accessioned 2015-05-25T07:13:17Z
- dc.date.available 2015-05-25T07:13:17Z
- dc.date.issued 2010ca
- dc.description.abstract Oxidative stress constitutes the basis of physio-pathological situations such as neurodegenerative diseases and aging. However, sublethal exposure to toxic molecules such as reactive oxygen species can induce cellular responses that result in stress fitness. Studies in Schizosaccharomyces pombe have recently showed that the Sty1 MAP kinase, known to be activated by hydrogen peroxide and other cellular stressors, plays a pivotal role in promoting fitness and longevity when it becomes activated by calorie restriction, a situation which induces oxidative metabolism and reactive oxygen species production. Activation of the MAP kinase by calorie restriction during logarithmic growth induces a transcriptional anti-stress response including genes essential to promote lifespan extension. Importantly enough, the lifespan promotion exerted by deletion of the pka1 or sck2 genes, inactivating the two main nutrient-responsive pathways, is dependent on the presence of a functional Sty1 stress pathway, since double mutants also lacking Sty1 or its main substrate Atf1 do not display extended viability. In this Research Perspective, we review these findings in relation to previous reports and extend important aspects of the original study. We propose that moderate stress levels that are not harmful for cells can make them stronger.en
- dc.description.sponsorship This work was supported by Dirección General de Investigación of Spain Grants BFU2006-02610 and BFU2009-06933, Plan E and FEDER, and by the Spanish program Consolider-Ingenio 2010 Grant /nCSD 2007-0020 to E.Hen
- dc.format.mimetype application/pdfca
- dc.identifier.citation Zuin A, Castellano-Esteve D, Ayté J, Hidalgo E. Living on the edge: stress and activation of stress responses promote lifespan extension. Aging. 2010;2(4):231-37. DOI: 10.18632/aging.100133ca
- dc.identifier.doi http://dx.doi.org/10.18632/aging.100133
- dc.identifier.issn 1945-4589ca
- dc.identifier.uri http://hdl.handle.net/10230/23632
- dc.language.iso engca
- dc.publisher Impact Journalsca
- dc.relation.ispartof Aging. 2010;2(4):231-37
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/BFU2006-02610
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-0020
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-06933
- dc.rights © Zuin et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword MAP kinase
- dc.subject.keyword Aging
- dc.subject.keyword Oxidative stress
- dc.subject.keyword Protein kinase A
- dc.subject.keyword Sty1
- dc.subject.keyword Sck2
- dc.subject.other Cèl·lules -- Envellimentca
- dc.subject.other Estrès oxidatiuca
- dc.subject.other Proteïnes quinasesca
- dc.title Living on the edge: stress and activation of stress responses promote lifespan extensionen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca