Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases
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- dc.contributor.author Rodríguez-Morató, Jose, 1987-ca
- dc.contributor.author Xicota Vila, Laura, 1987-ca
- dc.contributor.author Fitó Colomer, Montserratca
- dc.contributor.author Farré Albaladejo, Magíca
- dc.contributor.author Dierssen, Maraca
- dc.contributor.author Torre Fornell, Rafael de laca
- dc.date.accessioned 2015-11-16T15:27:34Z
- dc.date.available 2015-11-16T15:27:34Z
- dc.date.issued 2015
- dc.description.abstract Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers' attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Rodríguez-Morató J, Xicota L, Fitó M, Farré M, Dierssen M, de la Torre R. Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases. Molecules. 2015;20(3):4655-80. DOI: 10.3390/molecules20034655ca
- dc.identifier.doi http://dx.doi.org/10.3390/molecules20034655
- dc.identifier.issn 1420-3049
- dc.identifier.uri http://hdl.handle.net/10230/25108
- dc.language.iso catca
- dc.publisher MDPIca
- dc.relation.ispartof Molecules. 2015;20(3):4655-80
- dc.rights © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.keyword Olive oil
- dc.subject.keyword Phenolic compounds
- dc.subject.keyword Hydroxytyrosol
- dc.subject.keyword Tyrosol
- dc.subject.keyword Neurodegenerative diseases
- dc.subject.keyword Prevention
- dc.subject.keyword Neuroprotective agents
- dc.subject.other Fenols -- Efectes fisiològicsca
- dc.subject.other Nutrició -- Aspectes genètics
- dc.subject.other Sistema nerviós -- Degeneració
- dc.subject.other Oli d'oliva -- Ús terapèutic
- dc.title Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseasesca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca