Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
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- dc.contributor.author Shabestari, Maziarca
- dc.contributor.author Eriksen, Erik Finkca
- dc.contributor.author Paschalis, Eleftherios P.ca
- dc.contributor.author Roschger, Paulca
- dc.contributor.author Gamsjaeger, Sonjaca
- dc.contributor.author Klaushofer, Klausca
- dc.contributor.author Berzlanovich, Andreaca
- dc.contributor.author Nogués Solan, Francesc Xavierca
- dc.contributor.author Puig Verdié, Luísca
- dc.contributor.author Díez Pérez, Adolfoca
- dc.date.accessioned 2017-11-24T08:34:14Z
- dc.date.available 2017-11-24T08:34:14Z
- dc.date.issued 2017
- dc.description.abstract Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report we present the results of analysis of bone chips from a 74-year old female patient that had been on alendronate, ibandronate and denosumab treatment, and who sustained an atypical femoral fracture, by histology, quantitative backscattered electron imaging, and Raman spectroscopic analysis. The results indicate ongoing osteoclastic resorption, but also several abnormalities: 1) an altered arrangement of osteons; 2) impaired mineralization; 3) the presence of pyrophosphate, which might contribute to the impaired mineralization evident in the present case. Taken together, these changes may contribute to the focally reduced bone strength of this patient.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Shabestari M, Eriksen EF, Paschalis EP, Roschger P, Gamsjaeger S, Klaushofer K. et al. Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report. Bone Rep. 2017 Mar 2;6:81-86. DOI: 10.1016/j.bonr.2017.02.006
- dc.identifier.doi http://dx.doi.org/10.1016/j.bonr.2017.02.006
- dc.identifier.issn 2352-1872
- dc.identifier.uri http://hdl.handle.net/10230/33327
- dc.language.iso eng
- dc.publisher Elsevierca
- dc.relation.ispartof Bone Reports. 2017 Mar 2;6:81-6
- dc.rights Copyright © 2017 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Atypical femoral fracture
- dc.subject.keyword Pyrophosphate
- dc.subject.other Fractures
- dc.title Presence of pyrophosphate in bone from an atypical femoral fracture site: A case reportca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion