Cannabidiol decreases motivation for cocaine in a behavioral economics paradigm but does not prevent incubation of craving in mice

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Alegre Zurano, Laia
  • dc.contributor.author Berbegal-Sáez, Paula
  • dc.contributor.author Luján Pérez, Miguel Ángel, 1991-
  • dc.contributor.author Cantacorps Centellas, Lídia, 1991-
  • dc.contributor.author Martín Sánchez, Ana
  • dc.contributor.author García Baos, Alba
  • dc.contributor.author Valverde Granados, Olga
  • dc.date.accessioned 2022-03-07T07:34:39Z
  • dc.date.available 2022-03-07T07:34:39Z
  • dc.date.issued 2022
  • dc.description.abstract Cocaine is a highly consumed drug worldwide which directly targets brain areas involved in reinforcement processing and motivation. Cannabidiol is a phytocannabinoid that exerts protecting effects upon cocaine-induced addictive behavior, although many questions about the mechanisms of action and the specific affected processes remain unknown. Moreover, its effects on cue-induced cocaine-craving incubation have never been addressed. The present study aimed to assess the effects of cannabidiol (20 mg/kg, i.p.) administered during the acquisition of cocaine self-administration (0.75 mg/kg/infusion) and demand task or during cocaine abstinence and craving. Moreover, we measured the alterations in expression of AMPAR subunits and ERK1/2 phosphorylation due to cannabidiol treatment or cocaine withdrawal. Our results showed that cannabidiol reduced cocaine intake when administered during the acquisition phase of the self-administration paradigm, increased behavioral elasticity and reduced motivation for cocaine in a demand task. Cannabidiol also reduced GluA1/2 ratio and increased ERK1/2 phosphorylation in amygdala. No effects over cocaine-craving incubation were found when cannabidiol was administered during abstinence. Furthermore, cocaine withdrawal induced changes in GluA1 and GluA2 protein levels in the prelimbic cortex, ventral striatum and amygdala, as well as a decrease in ERK1/2 phosphorylation in ventral striatum. Taken together, our results show that cannabidiol exerts beneficial effects attenuating the acquisition of cocaine self-administration, in which an operant learning process is required. However, cannabidiol does not affect cocaine abstinence and craving.
  • dc.description.sponsorship This study was funded by the Ministerio de Ciencia, Innovación y Universidades (MCIU) and the Agencia Estatal de Investigación (AEI) (PID2019-104077RB-I00/AEI doi:10.1016/j.biopha.2022.112708.), Ministerio de Sanidad (RETICS-ISCIII, RD16/017/010 and Plan Nacional sobre Drogas 2018/007). L.A-Z received a FPI grant (BES-2017-080066) from Ministerio de Economia y Competitividad. P.B-S received a FI-AGAUR grant from the Generalitat de Catalunya (2021FI_B00205). A.G-B received a FI-AGAUR grant from the Generalitat de Catalunya (2019FI_B0081). The Department of Experimental and Health Sciences (UPF) is a “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Alegre-Zurano L, Berbegal-Sáez P, Luján MÁ, Cantacorps L, Martín-Sánchez A, García-Baos A, Valverde O. Cannabidiol decreases motivation for cocaine in a behavioral economics paradigm but does not prevent incubation of craving in mice. Biomed Pharmacother. 2022 Feb 12;148:112708. DOI: 10.1016/j.biopha.2022.112708
  • dc.identifier.doi http://dx.doi.org/10.1016/j.biopha.2022.112708
  • dc.identifier.issn 0753-3322
  • dc.identifier.uri http://hdl.handle.net/10230/52632
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Biomed Pharmacother. 2022 Feb 12;148:112708
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-104077RB-I00
  • dc.rights © 2022 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Behavioral economics
  • dc.subject.keyword Cannabidiol
  • dc.subject.keyword Cocaine
  • dc.subject.keyword Incubation
  • dc.subject.keyword Mice
  • dc.subject.keyword Self-administration
  • dc.title Cannabidiol decreases motivation for cocaine in a behavioral economics paradigm but does not prevent incubation of craving in mice
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)