The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Maurer, Marcusca
• dc.contributor.author Giménez Arnau, Anna Mariaca
• dc.contributor.author Balp, Maria Magdalenaca
• dc.date.accessioned 2018-03-21T08:02:03Z
• dc.date.available 2018-03-21T08:02:03Z
• dc.date.issued 2017
• dc.description.abstract BACKGROUND: Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for patients and physicians. Real-world evidence for the burden of CSU is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health-related quality of life (HRQoL) and work among patients with inadequately controlled CSU, and to describe its humanistic, societal, and economic burden. METHODS: This international observational study assessed a cohort of 673 adult patients with CSU whose symptoms persisted for ≥12 months despite treatment. Demographics, disease characteristics, and healthcare resource use in the previous 12 months were collected from medical records. Patient-reported data on urticaria and angioedema symptoms, HRQoL, and work productivity and activity impairment were collected from a survey and a diary. RESULTS: Almost 50% of patients had moderate-to-severe disease activity as reported by Urticaria Activity Score. Mean (SD) Dermatology Life Quality Index and Chronic Urticaria Quality of Life Questionnaire scores were 9.1 (6.62) and 33.6 (20.99), respectively. Chronic spontaneous urticaria markedly interfered with sleep and daily activities. Angioedema in the previous 12 months was reported by 66% of enrolled patients and significantly affected HRQoL. More than 20% of patients reported ≥1 hour per week of missed work; productivity impairment was 27%. These effects increased with increasing disease activity. Significant healthcare resources and costs were incurred to treat CSU. CONCLUSIONS: Chronic spontaneous urticaria has considerable humanistic and economic impacts. Patients with greater disease activity and with angioedema experience greater HRQoL impairments.
• dc.format.mimetype application/pdf
• dc.identifier.citation Maurer M, Abuzakouk M, Bérard F, Canonica W, Oude Elberink H, Giménez-Arnau A. et al. The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU. Allergy. 2017 Dec;72(12):2005-2016. DOI: 10.1111/all.13209
• dc.identifier.doi http://dx.doi.org/10.1111/all.13209
• dc.identifier.issn 0105-4538
• dc.identifier.uri http://hdl.handle.net/10230/34216
• dc.language.iso eng
• dc.publisher Wiley-Blackwellca
• dc.relation.ispartof Allergy. 2017 Dec;72(12):2005-16
• dc.rights Copyright © 2017 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the https://creativecommons.org/licenses/by-nc/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Angioedema
• dc.subject.keyword Economic burden
• dc.subject.keyword Observational study
• dc.subject.keyword Quality of life
• dc.subject.keyword Urticaria
• dc.subject.other Urticària -- Tractament
• dc.title The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSUca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion