Gestational sleep deprivation is associated with higher offspring body mass index and blood pressure

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Harskamp-van Ginkel, Margreet W.
  • dc.contributor.author Ierodiakonou, Despo
  • dc.contributor.author Margetaki, Katerina
  • dc.contributor.author Vafeiadi, Marina, 1983-
  • dc.contributor.author Karachaliou, Marianna
  • dc.contributor.author Kogevinas, Manolis
  • dc.contributor.author Vrijkotte, Tanja
  • dc.contributor.author Chatzi, Leda
  • dc.date.accessioned 2021-01-11T07:36:14Z
  • dc.date.available 2021-01-11T07:36:14Z
  • dc.date.issued 2020
  • dc.description.abstract Study objectives: The objective of this study was to evaluate the association between gestational sleep deprivation and childhood adiposity and cardiometabolic profile. Methods: Data were used from two population-based birth cohorts (Rhea study and Amsterdam Born Children and their Development study). A total of 3,608 pregnant women and their children were followed up until the age of 11 years. Gestational sleep deprivation was defined as 6 or fewer hours of sleep per day, reported by questionnaire. The primary outcomes included repeated measures of body mass index (BMI), waist circumference, body fat, serum lipids, systolic and diastolic blood pressure (DBP) levels in childhood. We performed a pooled analysis with adjusted linear mixed effect and Cox proportional hazards models. We tested for mediation by birthweight, gestational age, and gestational diabetes. Results: Gestational sleep deprivation was associated with higher BMI (beta; 95% CI: 0.7; 0.4, 1.0 kg/m2) and waist circumference (beta; 95% CI: 0.9; 0.1, 1.6 cm) in childhood, and increased risk for overweight or obesity (HR; 95% CI: 1.4; 1.1, 2.0). Gestational sleep deprivation was also associated with higher offspring DBP (beta; 95% CI: 1.6; 0.5, 2.7 mmHg). The observed associations were modified by sex (all p-values for interaction < 0.05); and were more pronounced in girls. Gestational diabetes and shorter gestational age partly mediated the seen associations. Conclusions: This is the first study showing that gestational sleep deprivation may increase offspring's adiposity and blood pressure, while exploring possible mechanisms. Attention to glucose metabolism and preterm birth might be extra warranted in mothers with gestational sleep deprivation.
  • dc.description.sponsorship We are thankful to all the mothers, fathers, and children who participated in the Rhea cohort and Amsterdam Born Children and their Development cohort. The ABCD study has been supported by grants from The Netherlands Organisation for Health Research and Development (ZonMW) and The Netherlands Heart Foundation. Research time of MH was supported by the municipal Amsterdam Healthy Weight Program (Amsterdamse Aanpak Gezond Gewicht). The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EUFP7-HEALTH-2012 Proposal No 308333 HELIX, FP7 European Union project, No. 264357 MeDALL), and the Ministry of health and social solidarity, Greece (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; Rhea Plus: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). Dr Lida Chatzi was supported by the National Institute of Environmental Health Sciences (NIEHS/National Institutes of Health (NIH)) grants: R21ES029681, R01ES030691, R01ES029944, R01 ES030364, R21ES028903, and P30ES007048, and by NIH (UH3OD023287). The study was also supported by Seventh Framework Programme and Hartstichting.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Harskamp-van Ginkel MW, Ierodiakonou D, Margetaki K, Vafeiadi M, Karachaliou M, Kogevinas M, et al.. Gestational sleep deprivation is associated with higher offspring body mass index and blood pressure. Sleep. 2020 Dec 14; 43(12): zsaa110. DOI: 10.1093/sleep/zsaa110
  • dc.identifier.doi http://dx.doi.org/10.1093/sleep/zsaa110
  • dc.identifier.issn 0161-8105
  • dc.identifier.uri http://hdl.handle.net/10230/46132
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.rights Copyright © Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword BMI
  • dc.subject.keyword DOHaD
  • dc.subject.keyword Adiposity
  • dc.subject.keyword Blood pressure
  • dc.subject.keyword Child
  • dc.subject.keyword Gestational sleep deprivation
  • dc.subject.keyword Obesity
  • dc.title Gestational sleep deprivation is associated with higher offspring body mass index and blood pressure
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)