Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

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• dc.contributor.author Barreiro Portela, Estherca
• dc.contributor.author Bustamante, Víctorca
• dc.contributor.author Curull Serrano, Víctorca
• dc.contributor.author Gea Guiral, Joaquimca
• dc.contributor.author Lopez-Campos, Jose Luisca
• dc.contributor.author Muñoz, Xavierca
• dc.date.accessioned 2018-03-15T09:12:02Z
• dc.date.available 2018-03-15T09:12:02Z
• dc.date.issued 2016
• dc.description.abstract Lung cancer (LC) has become one of the leading causes of preventable death in the last few decades. Cigarette smoking (CS) stays as the main etiologic factor of LC despite that many other causes such as occupational exposures, air pollution, asbestos, or radiation have also been implicated. Patients with chronic obstructive pulmonary disease (COPD), which also represents a major cause of morbidity and mortality in developed countries, exhibit a significantly greater risk of LC. The study of the underlying biological mechanisms that may predispose patients with chronic respiratory diseases to a higher incidence of LC has also gained much attention in the last few years. The present review has been divided into three major sections in which different aspects have been addressed: (I) relevant etiologic agents of LC; (II) studies confirming the hypothesis that COPD patients are exposed to a greater risk of developing LC; and (III) evidence on the most relevant underlying biological mechanisms that support the links between COPD and LC. Several carcinogenic agents have been described in the last decades but CS remains to be the leading etiologic agent in most geographical regions in which the incidence of LC is very high. Growing evidence has put the line forward the implications of COPD and especially of emphysema in LC development. Hence, COPD represents a major risk factor of LC in patients. Different avenues of research have demonstrated the presence of relevant biological mechanisms that may predispose COPD patients to develop LC. Importantly, the so far identified biological mechanisms offer targets for the design of specific therapeutic strategies that will further the current treatment options for patients with LC. Prospective screening studies, in which patients with COPD should be followed up for several years will help identify biomarkers that may predict the risk of LC among these patients.
• dc.description.sponsorship SEPAR 2008, FUCAP 2009, FUCAP 2011, FUCAP 2012, FIS 11/02029 (FEDER), FIS 14/00713 (FEDER), SAF2011-26908, and CIBERES (Instituto de Salud Carlos III) (Spain) have contributed to fund part of the research described in the review.
• dc.format.mimetype application/pdf
• dc.identifier.citation Barreiro E, Bustamante V, Curull V, Gea J, López-Campos JL, Muñoz X. Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights. J Thorac Dis. 2016 Oct;8(10):1122-35. DOI: 10.21037/jtd.2016.09.54
• dc.identifier.doi http://dx.doi.org/10.21037/jtd.2016.09.54
• dc.identifier.issn 2072-1439
• dc.identifier.uri http://hdl.handle.net/10230/34110
• dc.language.iso eng
• dc.publisher Pioneer Bioscience Pub. Co.ca
• dc.relation.ispartof Journal of Thoracic Disease. 2016 Oct;8(10):1122-35
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-26908
• dc.rights Copyright 2016 Journal of Thoracic Disease. All rights reserved.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Chronic obstructive pulmonary disease (COPD)
• dc.subject.keyword Epidemics
• dc.subject.keyword Etiologic agents
• dc.subject.keyword Lung cancer (LC)
• dc.subject.keyword Underlying biological mechanisms
• dc.subject.other Pulmons -- Càncer
• dc.subject.other Pulmons -- Malalties obstructives
• dc.title Relationships between chronic obstructive pulmonary disease and lung cancer: biological insightsca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion