Childhood body composition trajectories and adolescent lung function. Findings from the ALSPAC study

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• dc.contributor.author Peralta, Gabriela P.
• dc.contributor.author Fuertes, Elaine
• dc.contributor.author Granell, Raquel
• dc.contributor.author Mahmoud, Osama
• dc.contributor.author Roda, Célina
• dc.contributor.author Serra, Ignasi
• dc.contributor.author Jarvis, Deborah
• dc.contributor.author Henderson, John
• dc.contributor.author García Aymerich, Judith
• dc.date.accessioned 2020-01-15T10:21:47Z
• dc.date.available 2020-01-15T10:21:47Z
• dc.date.issued 2019
• dc.description.abstract Rationale: Body composition changes throughout life may explain the inconsistent associations reported between body mass index and lung function in children. Objectives: To assess the associations of body weight and composition trajectories from 7 to 15 years with lung function at 15 years and lung function growth between 8 and 15 years. Methods: Sex-specific body mass index, lean body mass index, and fat mass index trajectories were developed using Group-Based Trajectory Modeling on data collected at least twice between 7 and 15 years from 6,964 children (49% boys) in the UK Avon Longitudinal Study of Parents and Children birth cohort. Associations of these trajectories with post-bronchodilation lung function parameters at 15 years and with lung function growth rates from 8 to 15 years were assessed using multivariable linear regression models, stratified by sex, in a subgroup with lung function data (n = 3,575). Measurements and Main Results: For all body mass measures we identified parallel trajectories that increased with age. There was no consistent evidence of an association between the body mass index trajectories and lung function measures. Higher lean body mass index trajectories were associated with higher levels and growth rates of FVC, FEV1, and forced expiratory flow, midexpiratory phase in both sexes (e.g., boys in the highest lean body mass index trajectory had on average a 0.62 L [95% confidence interval, 0.44-0.79; P trend < 0.0001] higher FVC at 15 yr than boys in the lowest trajectory). Increasing fat mass index trajectories were associated with lower levels and growth rates of FEV1 and forced expiratory flow, midexpiratory phase only in boys and lower levels of FEV1/FVC in both sexes. Conclusions: Higher lean body mass during childhood and adolescence is consistently associated with higher lung function at 15 years in both sexes, whereas higher fat mass is associated with lower levels of only some lung function parameters.
• dc.description.sponsorship The present analyses are part of the ALEC (Ageing Lungs in European Cohorts) Study (www.alecstudy.org), which has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 633212. The content of this article reflects only the authors’ views, and the European Commission is not liable for any use that may be made of the information contained therein. The UK Medical Research Council and Wellcome Trust (grant reference number: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grant funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). Specifically, grants from Wellcome Trust and Medical Research Council (076467/Z/05/Z and G0401540/73080) supported the collection of body composition and lung function data at 15 years. E.F. is supported by a Marie Skłodowska-Curie Individual Fellowship (H2020-MSCA-IF-2015; proposal number 704268). C.R. is the recipient of a European Respiratory Society Fellowship (RESPIRE3-201703-00127, under H2020—Marie Skłodowska-Curie Actions COFUND).
• dc.format.mimetype application/pdf
• dc.identifier.citation Peralta GP, Fuertes E, Granell R, Mahmoud O, Roda C, Serra I et al. Childhood body composition trajectories and adolescent lung function. Findings from the ALSPAC study. Am J Respir Crit Care Med. 2019;200(1):75-83. DOI: 10.1164/rccm.201806-1168OC
• dc.identifier.doi http://dx.doi.org/10.1164/rccm.201806-1168OC
• dc.identifier.issn 1073-449X
• dc.identifier.uri http://hdl.handle.net/10230/43287
• dc.language.iso eng
• dc.publisher American Thoracic Society
• dc.relation.ispartof American Journal of Respiratory and Critical Care Medicine. 2019;200(1):75-83
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/704268
• dc.rights Copyright © 2019 by the American Thoracic Society. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). For commercial usage and reprints, please contact Diane Gern (dgern@thoracic.org).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword ALSPAC
• dc.subject.keyword Children
• dc.subject.keyword Epidemiology
• dc.subject.keyword Respiratory health
• dc.title Childhood body composition trajectories and adolescent lung function. Findings from the ALSPAC study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion