The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort

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  • dc.contributor.author Sarzo, Blanca
  • dc.contributor.author Ballester Díez, Ferran
  • dc.contributor.author Soler Blasco, Raquel
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Lopez-Espinosa, Maria-José
  • dc.contributor.author Ibarluzea, Jesús
  • dc.contributor.author Lozano, Manuel
  • dc.contributor.author Julvez, Jordi
  • dc.contributor.author Iriarte, Gorka
  • dc.contributor.author Subiza-Pérez, Mikel
  • dc.contributor.author González-Safont, Llúcia
  • dc.contributor.author Fernández-Somoano, Ana
  • dc.contributor.author Vallejo Ortega, Jorge
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author López González, Ulises Alfredo
  • dc.contributor.author Riaño-Galán, Isolina
  • dc.contributor.author Riutort-Mayol, Gabriel
  • dc.contributor.author Murcia, Mario
  • dc.contributor.author Llop, Sabrina
  • dc.date.accessioned 2024-07-08T13:05:11Z
  • dc.date.available 2024-07-08T13:05:11Z
  • dc.date.issued 2024
  • dc.description.abstract The objective is to investigate the relation between cord blood mercury concentrations and child neurobehavioural functioning assessed longitudinally during childhood until pre-adolescence. Methods: The study involves mothers and their offspring engaged in the Spanish INMA birth cohort (n = 1147). Total mercury (THg) was determined in cord blood. Behavioural problems were assessed several times during childhood using the ADHD-DSM-IV at age 4, SDQ at ages 7 and 11, CPRS-R:S and the CBCL at ages 7, 9 and 11. Covariates were obtained through questionnaires during the whole period. Multivariate generalised negative binomial (MGNB) models or mixed-effects MGNB (for those tests with information at one or more time points, respectively) were used to investigate the relation between cord blood THg and the children's punctuations. Models were adjusted for prenatal fish intake. Effect modification by sex, prenatal and postnatal fish intake, prenatal fruit and vegetable intake, and maternal polychlorinated biphenyl concentrations (PCBs) was assessed by interaction terms. Results: The geometric mean ± standard deviation of cord blood THg was 8.22 ± 2.19 μg/L. Despite adjusting for fish consumption, our results did not show any statistically significant relationship between prenatal Hg and the children's performance on behavioural tests conducted between the ages of 4 and 11. Upon assessing the impact of various factors, we observed no statistically significant interaction. Conclusion: Despite elevated prenatal THg exposure, no association was found with children's behavioural functioning assessed from early childhood to pre-adolescence. The nutrients in fish could offset the potential neurotoxic impact of Hg. Further birth cohort studies with longitudinal data are warranted.
  • dc.description.sponsorship This study was funded by grants from the Instituto de Salud Carlos III (CD23/00090 [co-financied by European Union], Red INMA G03/176; CB06/02/0041; PI041436; PI042018; PI081151, PI09/00090. [co-financed by FEDER funds]: PI09/02311, PI13/02429, PI12/01890, PI 13/00054, PI13/1944, PI15/00118, PI 16/00128; PI16/1288, PI16/00118, PI16/00261, PI16/00261, PI17/01340, PI17/00663, PI18/00909, PI18/00547, PI18/00018, PI18/01142, PI19/1338, PI21/00266, PI23/1578, Miguel Servet-FEDER: CP15/0025, CP18/00018, CPII19/00015, CPII20/00006; CD21/00186; FIS-FSE: 17/00260; Miguel Servet-FSE: MS15/0025, MSII16/00051, MS20/0006), CIBERESP, Fundación Cajastur, Universidad de Oviedo, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794, 634453, H2020-EU No 874583 ATHLETE project). We also acknowledge the support of the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033, the Generalitat de Catalunya through the CERCA Programme. In addition, this study was supported by grants from the Generalitat Valenciana, Spain (CIAICO/2021/132, BEST/2020/059 and AICO, 2020/285), the Alicia Koplowitz Foundation 2017, the Department of Health of the Basque Government [2005111093 and GVSAN2018111086], the Provincial Government of Gipuzkoa [DFG06/002], annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain), and the Spanish Government through the Spanish Ministry of Universities (Margarita Salas Grant MS21-125, Grant CAS21/00008 and Grant for the requalification of the Spanish University).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Sarzo B, Ballester F, Soler-Blasco R, Sunyer J, Lopez-Espinosa MJ, Ibarluzea J, et al. The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort. Environ Res. 2024 Jul 1;252(Pt 2):118954. DOI: 10.1016/j.envres.2024.118954
  • dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2024.118954
  • dc.identifier.issn 0013-9351
  • dc.identifier.uri http://hdl.handle.net/10230/60694
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Environ Res. 2024 Jul 1;252(Pt 2):118954
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.rights © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Behaviour
  • dc.subject.keyword Child
  • dc.subject.keyword Fish consumption
  • dc.subject.keyword Mercury
  • dc.subject.keyword Neurotoxicity
  • dc.title The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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