The interplay between DNA methylation and sequence divergence in recent human evolution

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  • dc.contributor.author Hernando Herráez, Irene, 1985-ca
  • dc.contributor.author Heyn, Holgerca
  • dc.contributor.author Fernández Callejo, Marcosca
  • dc.contributor.author Vidal, Enriqueca
  • dc.contributor.author Fernández Bellon, Hugoca
  • dc.contributor.author Prado Martínez, Javier, 1987-ca
  • dc.contributor.author Sharp, Andrew J.ca
  • dc.contributor.author Esteller, Manelca
  • dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
  • dc.date.accessioned 2016-01-27T18:13:00Z
  • dc.date.available 2016-01-27T18:13:00Z
  • dc.date.issued 2015
  • dc.description.abstract Despite the increasing knowledge about DNA methylation, the understanding of human epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we identified hundreds of differentially methylated regions (DMRs) in humans compared to non-human primates and estimated that ∼25% of these regions were detectable throughout several human tissues. Human DMRs were enriched for specific histone modifications and the majority were located distal to transcription start sites, highlighting the importance of regions outside the direct regulatory context. We also found a significant excess of endogenous retrovirus elements in human-specific hypomethylated.We reported for the first time a close interplay between inter-species genetic and epigenetic variation in regions of incomplete lineage sorting, transcription factor binding sites and human differentially hypermethylated regions. Specifically, we observed an excess of human-specific substitutions in transcription factor binding sites located within human DMRs, suggesting that alteration of regulatory motifs underlies some human-specific methylation patterns. We also found that the acquisition of DNA hypermethylation in the human lineage is frequently coupled with a rapid evolution at nucleotide level in the neighborhood of these CpG sites. Taken together, our results reveal new insights into the mechanistic basis of human-specific DNA methylation patterns and the interpretation of inter-species non-coding variation.ca
  • dc.description.sponsorship We acknowledge support from AGAUR (Generalitat de Catlunya, Spain) and the Barcelona Zoo (Ajuntament de Barcelona) for an award to I.H.H. H.H. is a Miguel Servet (CP14/00229) researcher funded by the Spanish Institute of Health Carlos III (ISCIII).T.M.B. and M.E. are ICREA Research Professors. Funding for open access charge: European Research Council (ERC), grant EPINORC, under agreement No. 268626; MICINN Projects—SAF2011-22803 and BFU2011-28549; Cellex Foundation; European Community's Seventh Framework Programme (FP7/2007-2013), grant HEALTH-F5-2011-282510—BLUEPRINT, and the Health and Science Departments of the Generalitat de Catalunya.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Hernando-Herraez I, Heyn H, Fernandez-Callejo M, Vidal E, Fernandez-Bellon H, Prado-Martinez J et al. The interplay between DNA methylation and sequence divergence in recent human evolution. Nucleic acids research. 2015; 43(17): 8204-8214. DOI 10.1093/nar/gkv693ca
  • dc.identifier.doi http://dx.doi.org/10.1093/nar/gkv693
  • dc.identifier.issn 0305-1048
  • dc.identifier.uri http://hdl.handle.net/10230/25672
  • dc.language.iso engca
  • dc.publisher Oxford University Pressca
  • dc.relation.ispartof Nucleic acids research. 2015; 43(17): 8204-8214
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282510
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/ERC/268626
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-22803
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28549
  • dc.rights © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Goril·lesca
  • dc.subject.other ADNca
  • dc.subject.other Evolució molecularca
  • dc.title The interplay between DNA methylation and sequence divergence in recent human evolutionca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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