Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development

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• dc.contributor.author Mijimolle, Nievesca
• dc.contributor.author Velasco, Juanca
• dc.contributor.author Dubus, Pierreca
• dc.contributor.author Guerra, Carmenca
• dc.contributor.author Weinbaum, Carolyn A.ca
• dc.contributor.author Casey, Patrick J.ca
• dc.contributor.author Campuzano Uceda, María Victoriaca
• dc.contributor.author Barbacid, Marianoca
• dc.date.accessioned 2016-02-18T14:21:44Z
• dc.date.available 2016-02-18T14:21:44Z
• dc.date.issued 2005
• dc.description.abstract Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development.ca
• dc.description.sponsorship This work was supported by grants from the V Framework Programme of the European Union (QLK3-1999-00875) to M.B. and from the Ministerio de Ciencia y Tecnologia (SAF2001-0058) and Fondo de Investigación Sanitaria (00/0109) to J.V. P.D. was supported by the Association pour la Recherche contre le Cancer (ARC). P.J.C. was supported by NIH grant GM46372. N.M. was supported by a BEFI Fellowship from the Fondo de Investigación Sanitaria. The CNIO is partially supported by the RTICCC (Red de Centros de Cáncer; FIS C03/10)
• dc.format.mimetype application/pdfca
• dc.identifier.citation Mijimolle N, Velasco J, Dubus P, Guerra C, Weinbaum CA, Casey PJ et al. Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer cell. 2005;7(4):313-24. DOI: 10.1016/j.ccr.2005.03.004ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.ccr.2005.03.004
• dc.identifier.issn 1535-6108
• dc.identifier.uri http://hdl.handle.net/10230/25884
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Cancer cell. 2005;7(4):313-24
• dc.rights © Elsevier. This is the published version of an article http://dx.doi.org/10.1016/j.ccr.2005.03.004 that appeared in the journal Cancer cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Homeòstasica
• dc.subject.other Tumorsca
• dc.title Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor developmentca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca