High frequency of acute decompensation and cancer in patients with compensated cirrhosis due to nonalcoholic fatty liver disease: A retrospective cohort study
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- dc.contributor.author Bassegoda, Octavi
- dc.contributor.author Rivera-Esteban, Jesús
- dc.contributor.author Serra, Isabel
- dc.contributor.author Morillas, Rosa M.
- dc.contributor.author Broquetas, Teresa
- dc.contributor.author Vergara, Mercè
- dc.contributor.author Rodriguez, Adrià
- dc.contributor.author Aracil, Carles
- dc.contributor.author Virolés, Silvia
- dc.contributor.author Carrión Rodríguez, José Antonio
- dc.contributor.author Pardo, Albert
- dc.contributor.author Rodríguez-Tajes, Sergio
- dc.contributor.author Serra Burriel, Miquel
- dc.contributor.author Pericàs, Juan
- dc.contributor.author Augustin, Salvador
- dc.contributor.author Ginès, Pere
- dc.contributor.author Graupera, Isabel
- dc.date.accessioned 2023-01-26T07:33:43Z
- dc.date.available 2023-01-26T07:33:43Z
- dc.date.issued 2022
- dc.description.abstract The natural history of compensated cirrhosis due to nonalcoholic fatty liver disease (NAFLD) has not been completely characterized. The aim of the present study was to assess the incidence and risk factors of acute decompensation of cirrhosis, hepatocellular carcinoma, and extrahepatic cancers. This was a multicenter, retrospective, cohort study including 449 patients with compensated cirrhosis due to NAFLD. We calculated cumulative incidences and used competitive risk analysis to determine the risk factors associated with decompensation and cancer development. Over a median of 39 months of follow-up, 124 patients (28%) presented acute decompensation. The most frequent decompensation was ascites (21%) followed by hepatic encephalopathy (15%), variceal bleeding (9%), and spontaneous bacterial peritonitis (3%). Acute-on-chronic liver failure was diagnosed in 6% of patients during follow-up. Liver function parameters and specifically an albumin level below 40 g/L were independently associated with an increased risk of decompensation. The presence of ischemic heart disease was independently associated with acute decompensation. Seventy-eight patients (18%) developed hepatocellular carcinoma or extrahepatic cancers during follow-up (51 and 27, respectively). Conclusion: Patients with compensated cirrhosis due to NAFLD are at high risk of severe liver complications, such as the development of acute decompensation, in a relative short follow-up time. This population is at high risk of hepatic and extrahepatic cancers.
- dc.format.mimetype application/pdf
- dc.identifier.citation Bassegoda O, Rivera-Esteban J, Serra I, Morillas R, Broquetas T, Vergara M, Rodriguez A, Aracil C, Virolés S, Carrión JA, Pardo A, Rodríguez-Tajes S, Serra-Burriel M, Pericàs JM, Augustin S, Ginès P, Graupera I. High frequency of acute decompensation and cancer in patients with compensated cirrhosis due to nonalcoholic fatty liver disease: A retrospective cohort study. Hepatol Commun. 2022 Nov;6(11):3212-22. DOI: 10.1002/hep4.2056
- dc.identifier.doi http://dx.doi.org/10.1002/hep4.2056
- dc.identifier.issn 2471-254X
- dc.identifier.uri http://hdl.handle.net/10230/55443
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Hepatol Commun. 2022 Nov;6(11):3212-22
- dc.rights © 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.title High frequency of acute decompensation and cancer in patients with compensated cirrhosis due to nonalcoholic fatty liver disease: A retrospective cohort study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion