Early-life external exposome in children 2-5 years old in Colombia

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• dc.contributor.author Marín, Diana
• dc.contributor.author Basagaña Flores, Xavier
• dc.contributor.author Domínguez, Alan
• dc.contributor.author Rueda, Zulma Vanessa
• dc.date.accessioned 2024-07-10T17:18:31Z
• dc.date.available 2024-07-10T17:18:31Z
• dc.date.issued 2024
• dc.description.abstract Exposome studies are advancing in high-income countries to understand how multiple environmental exposures impact health. However, there is a significant research gap in low- and middle-income and tropical countries. We aimed to describe the spatiotemporal variation of the external exposome, its correlation structure between and within exposure groups, and its dimensionality. A one-year follow-up cohort study of 506 children under 5 in two cities in Colombia was conducted to evaluate asthma, acute respiratory infections, and DNA damage. We examined 48 environmental exposures during pregnancy and 168 during childhood in eight exposure groups, including atmospheric pollutants, natural spaces, meteorology, built environment, traffic, indoor exposure, and socioeconomic capital. The exposome was estimated using geographic information systems, remote sensing, spatiotemporal modeling, and questionnaires. The median age of children at study entry was 3.7 years (interquartile range: 2.9-4.3). Air pollution and natural spaces exposure decreased from pregnancy to childhood, while socioeconomic capital increased. The highest median correlations within exposure groups were observed in meteorology (r = 0.85), traffic (r = 0.83), and atmospheric pollutants (r = 0.64). Important correlations between variables from different exposure groups were found, such as atmospheric pollutants and meteorology (r = 0.76), natural spaces (r = -0.34), and the built environment (r = 0.53). Twenty principal components explained 70%, and 57 explained 95% of the total variance in the childhood exposome. Our findings show that there is an important spatiotemporal variation in the exposome of children under 5. This is the first characterization of the external exposome in urban areas of Latin America and highlights its complexity, but also the need to better characterize and understand the exposome in order to optimize its analysis and applications in local interventions aimed at improving the health conditions and well-being of the child population and contributing to environmental health decision-making.
• dc.format.mimetype application/pdf
• dc.identifier.citation Marín D, Basagaña X, Amaya F, Aristizábal LM, Muñoz DA, Domínguez A, et al. Early-life external exposome in children 2-5 years old in Colombia. Environ Res. 2024 Jul 1;252(Pt 3):118913. DOI: 10.1016/j.envres.2024.118913
• dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2024.118913
• dc.identifier.issn 0013-9351
• dc.identifier.uri http://hdl.handle.net/10230/60719
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Res. 2024 Jul 1;252(Pt 3):118913
• dc.rights © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Children
• dc.subject.keyword Environmental exposure
• dc.subject.keyword Exposome
• dc.subject.keyword Latin America
• dc.subject.keyword Pregnancy
• dc.title Early-life external exposome in children 2-5 years old in Colombia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion