Ambient air pollution and newborn size and adiposity at birth: differences by maternal ethnicity (the born in Bradford study cohort)

Schembari, Anna, 1982-; de Hoogh, Kees; Pedersen, Marie; Dadvand, Payam; Martínez Muriano, David; Hoek, Gerard; Petherick, Emily S.; Wright, John; Nieuwenhuijsen, Mark J.

Ambient air pollution and newborn size and adiposity at birth: differences by maternal ethnicity (the born in Bradford study cohort)

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dc.contributor.author Schembari, Anna, 1982-ca
dc.contributor.author de Hoogh, Keesca
dc.contributor.author Pedersen, Marieca
dc.contributor.author Dadvand, Payamca
dc.contributor.author Martínez Muriano, Davidca
dc.contributor.author Hoek, Gerardca
dc.contributor.author Petherick, Emily S.ca
dc.contributor.author Wright, Johnca
dc.contributor.author Nieuwenhuijsen, Mark J.ca
dc.date.accessioned 2016-05-26T17:16:14Z
dc.date.available 2016-05-26T17:16:14Z
dc.date.issued 2015
dc.description.abstract BACKGROUND: Exposure to ambient air pollution has been associated with reduced size of newborns; however, the modifying effect of maternal ethnicity remains little explored among South Asians. OBJECTIVES: We investigated ethnic differences in the association between ambient air pollution and newborn's size. METHOD: Pregnant women were recruited between 2007 and 2010 for the Born in Bradford cohort study, in England. Exposures to particulate matter (≤ 10 μm, PM10; ≤ 2.5 μm, PM2.5), PM2.5 absorbance, and nitrogen oxides (NOx, NO2) were estimated using land-use regressions models. Using multivariate linear regression models, we evaluated effect modification by maternal ethnicity ("white British" or "Pakistani origin," self-reported) on the associations of air pollution and birth weight, head circumference, and triceps and subscapular skinfold thickness. RESULTS: A 5-μg/m3 increase in mean third trimester PM2.5 was associated with significantly lower birth weight and smaller head circumference in children of white British mothers (-43 g; 95% CI: -76, -10 and -0.28 cm; 95% CI: -0.39, -0.17, respectively), but not in children of Pakistani origin (9 g; 95% CI: -17, 35 and -0.08 cm; 95% CI: -0.17, 0.01, respectively) (p(int) = 0.03 and < 0.001). In contrast, PM2.5 was associated with significantly larger triceps and subscapular skinfold thicknesses in children of Pakistani origin (0.17 mm; 95% CI: 0.08, 0.25 and 0.21 mm; 95% CI: 0.12, 0.29, respectively), but not in white British children (-0.02 mm; 95% CI: -0.14, 0.01 and 0.06 mm; 95% CI: -0.06, 0.18, respectively) (p(int) = 0.06 and 0.11). Patterns of associations for PM10 and PM2.5 absorbance according to ethnicity were similar to those for PM2.5, but associations of the outcomes with NO2 and NOx were mostly nonsignificant in both ethnic groups. CONCLUSIONS: Our results suggest that associations of ambient PM exposures with newborn size and adiposity differ between white British and Pakistani origin infants.ca
dc.description.sponsorship This project was jointly supported by the ESCAPE (European Study of Cohorts for Air Pollution Effects) project funded under the European Union’s Seventh Framework Programme (grant agreement number 211250), and the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) Yorkshire and Humberside Programme. A.S. holds a predoctoral fellowship awarded from the Spanish Ministry of Economy and Finance, Instituto de Salud Carlos III-FEDER fellowship (PFIS grant FI 10/00476); M.P. holds a “Juan de la Cierva” postdoctoral fellowship awarded by the Spanish Ministry of Science and Innovation (JCI-2011-09937). P.D. holds a “Ramón y Cajal” fellowship (RYC-2012-10995) awarded by the Spanish Ministry of Economy and Competitiveness.
dc.format.mimetype application/pdfca
dc.identifier.citation Schembari A, de Hoogh K, Pedersen M, Dadvand P, Martinez D, Hoek G et al. Ambient air pollution and newborn size and adiposity at birth: differences by maternal ethnicity (the born in Bradford study cohort). Environmental health perspectives. 2015; 123(11): 1208-1215. DOI 10.1289/ehp.1408675ca
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1408675
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/26765
dc.language.iso engca
dc.publisher National Institute of Environmental Health Sciencesca
dc.relation.ispartof Environmental health perspectives. 2015; 123(11): 1208-1215
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/JCI2011-09937
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/RYC2012-10995
dc.rights Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/ehp.1408675ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Aire -- Contaminacióca
dc.subject.other Embaràsca
dc.subject.other Infants nadonsca
dc.title Ambient air pollution and newborn size and adiposity at birth: differences by maternal ethnicity (the born in Bradford study cohort)ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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