Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
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- dc.contributor.author Paternoster, Lavinia
- dc.contributor.author Gonzalez, Juan Ramon
- dc.contributor.author Bustamante Pineda, Mariona
- dc.contributor.author Tejedor, Elisabeth
- dc.contributor.author Sunyer Deu, Jordi
- dc.contributor.author Weidinger, Stephan
- dc.date.accessioned 2019-07-03T07:57:21Z
- dc.date.available 2019-07-03T07:57:21Z
- dc.date.issued 2015
- dc.description.abstract Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.
- dc.description.sponsorship This research was specifically funded by an MRC Population Health Scientist Fellowship awarded to Dr L Paternoster (MR/J012165/1). D.M.E. is supported by an Australian Research Council Future Fellowship (FT130101709) and a Medical Research Council program grant (MC_UU_12013/4)
- dc.format.mimetype application/pdf
- dc.identifier.citation Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP et al. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet. 2015 Dec;47(12):1449-56. DOI: 10.1038/ng.3424
- dc.identifier.doi http://dx.doi.org/10.1038/ng.3424
- dc.identifier.issn 1061-4036
- dc.identifier.uri http://hdl.handle.net/10230/41920
- dc.language.iso eng
- dc.publisher Nature Research
- dc.relation.ispartof Nature Genetics. 2015 Dec;47(12):1449-56
- dc.rights © Springer Nature Publishing AG. Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP et al. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet. 2015 Dec; 47(12): 1449-1456. http://dx.doi.org/10.1038/ng.3424
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Dermatitis atòpica
- dc.subject.other Grups ètnics
- dc.subject.other Genètica
- dc.subject.other Genomes
- dc.title Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion