The contribution of historical processes to contemporary extinction risk in placental mammals

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• dc.contributor.author Wilder, Aryn P.
• dc.contributor.author Supple, Megan A.
• dc.contributor.author Subramanian, Ayshwarya
• dc.contributor.author Mudide, Anish
• dc.contributor.author Swofford, Ross
• dc.contributor.author Serres-Armero, Aitor
• dc.contributor.author Steiner, Cynthia
• dc.contributor.author Koepfli, Klaus-Peter
• dc.contributor.author Genereux, Diane P.
• dc.contributor.author Karlsson, Elinor K.
• dc.contributor.author Lindblad-Toh, Kerstin
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-
• dc.contributor.author Muñoz-Fuentes, Violeta
• dc.contributor.author Foley, Kathleen
• dc.contributor.author Meyer, Wynn K.
• dc.contributor.author Zoonomia Consortium
• dc.contributor.author Ryder, Oliver A.
• dc.contributor.author Shapiro, Beth
• dc.date.accessioned 2024-03-25T07:10:16Z
• dc.date.available 2024-03-25T07:10:16Z
• dc.date.issued 2023
• dc.description.abstract Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic variation across single genomes of 240 mammals that compose the Zoonomia alignment to evaluate how historical effective population size (Ne) affects heterozygosity and deleterious genetic load and how these factors may contribute to extinction risk. We find that species with smaller historical Ne carry a proportionally larger burden of deleterious alleles owing to long-term accumulation and fixation of genetic load and have a higher risk of extinction. This suggests that historical demography can inform contemporary resilience. Models that included genomic data were predictive of species' conservation status, suggesting that, in the absence of adequate census or ecological data, genomic information may provide an initial risk assessment.
• dc.description.sponsorship Funding was provided by NIH grant R01 HG008742 (E.K.K.); the Swedish Research Council Distinguished Professor Award (K.L.-T.); the Wallenberg Foundation (K.L.-T.); European Research Council European Union’s Horizon 2020 864203 (T.M.-B.); MINECO/FEDER, UE grant BFU2017-86471-P (T.M.-B.); Agencia Estatal de Investigación “Unidad de Excelencia María de Maeztu” CEX2018-000792-M (T.M.-B.); a Howard Hughes International Early Career award (T.M.-B.); Secretaria d’Universitats i Recerca (T.M.-B.); and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (T.M.-B.).
• dc.format.mimetype application/pdf
• dc.identifier.citation Wilder AP, Supple MA, Subramanian A, Mudide A, Swofford R, Serres-Armero A, et al. The contribution of historical processes to contemporary extinction risk in placental mammals. Science. 2023 Apr 28;380(6643):eabn5856. DOI: 10.1126/science.abn5856
• dc.identifier.doi http://dx.doi.org/10.1126/science.abn5856
• dc.identifier.issn 0036-8075
• dc.identifier.uri http://hdl.handle.net/10230/59553
• dc.language.iso eng
• dc.publisher American Association for the Advancement of Science (AAAS)
• dc.relation.ispartof Science. 2023 Apr 28;380(6643):eabn5856
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/864203
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/CEX2018-000792-M
• dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science. 2023 Apr 28;380(6643):eabn5856, DOI: 10.1126/science.abn5856.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Variació (Biologia)
• dc.subject.other Genètica
• dc.title The contribution of historical processes to contemporary extinction risk in placental mammals
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion