The "CPC clip motif": a conserved structural signature for heparin-binding proteins
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- dc.contributor.author Torrent, Marcca
- dc.contributor.author Nogués, Victòria M.ca
- dc.contributor.author Andreu Martínez, Davidca
- dc.contributor.author Boix, Esterca
- dc.date.accessioned 2015-05-12T09:46:55Z
- dc.date.available 2015-05-12T09:46:55Z
- dc.date.issued 2012ca
- dc.description.abstract Glycosaminoglycans (GAGs) are essential molecules that regulate diverse biological processes including cell adhesion, differentiation, signaling and growth, by interaction with a wide variety of proteins. However, despite the efforts committed to understand the molecular nature of the interactions in protein-GAG complexes, the answer to this question remains elusive. In the present study the interphases of 20 heparin–binding proteins have been analyzed searching for a conserved structural pattern. We have found that a structural motif encompassing one polar and two cationic residues (which has been named the CPC clip motif) is conserved among all the proteins deposited in the PDB. The distances between the α carbons and the side chain center of gravity of the residues composing this motif are also conserved. Furthermore, this pattern can be found in other proteins suggested to bind heparin for which no structural information is available. Hence we propose that the CPC clip motif, working like a staple, is a primary contributor to the attachment of heparin and other sulfated GAGs to heparin-binding proteins.en
- dc.description.sponsorship MT is the recipient of a postdoctoral grant from Alianza Cuatro Universidades (Spain). Work supported by the European Union (HEALTH-F3-2008- 223414), the Spanish Ministry of Science and Innovation (BIO2008-04487-CO3-02, BFU2009- 09371, FEDER funds) and the Generalitat de Catalunya (SGR 2009-494, SGR2009-795en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Torrent M, Nogues MV, Andreu D, Boix E. The "CPC clip motif": a conserved structural signature for heparin-binding proteins. PLoS ONE. 2012;7(8):e42692. DOI: 10.1371/journal.pone.0042692ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0042692
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23554
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2012;7(8):e42692
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/223414ca
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2008-04487
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009- 09371
- dc.rights © Torrent et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Aminoàcidsca
- dc.subject.other Proteïnes -- Metabolismeca
- dc.title The "CPC clip motif": a conserved structural signature for heparin-binding proteinsen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca