Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice

Gómez-Sotres, Paula; Skupio, Urszula; Dalla Tor, Tommaso; Julio-Kalajzić, Francisca; Cannich, Astrid; Gisquet, Doriane; Bonilla-Del Río, Itziar; Drago, Filippo; Puente, Nagore; Grandes, Pedro; Bellocchio, Luigi; Busquets Garcia, Arnau, 1985-; Bains, Jaideep S.; Marsicano, Giovanni

Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice

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dc.contributor.author Gómez-Sotres, Paula
dc.contributor.author Skupio, Urszula
dc.contributor.author Dalla Tor, Tommaso
dc.contributor.author Julio-Kalajzić, Francisca
dc.contributor.author Cannich, Astrid
dc.contributor.author Gisquet, Doriane
dc.contributor.author Bonilla-Del Río, Itziar
dc.contributor.author Drago, Filippo
dc.contributor.author Puente, Nagore
dc.contributor.author Grandes, Pedro
dc.contributor.author Bellocchio, Luigi
dc.contributor.author Busquets Garcia, Arnau, 1985-
dc.contributor.author Bains, Jaideep S.
dc.contributor.author Marsicano, Giovanni
dc.date.accessioned 2025-07-08T06:35:40Z
dc.date.available 2025-07-08T06:35:40Z
dc.date.issued 2024
dc.description.abstract Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning.
dc.description.sponsorship This study was funded by Inserm (to G.M); the European Research Council (Micabra, ERC-2017-AdG-786467, to G.M); Fondation pour la Recherche Medicale (DRM20101220445, to G.M; SPF201809006908 to U.S); the Human Frontiers Science Program (to G.M); Region Aquitaine (CanBrain, AAP2022A-2021-16763610 and −17219710 to G.M); French State/Agence Nationale de la Recherche (ERA-Net Neuron CanShank, ANR-21-NEU2-0001-04, to G.M), (CaMeLS, ANR-23-CE16-0022-01, to G.M), (Hippobese, ANR-23-CE14-0004-03, to G.M); the French government in the framework of the University of Bordeaux IdEx “Investments for the Future” program / GPR BRAIN_2030 (to P.G-S and G.M) and Bordeaux Collaboration Scheme (to P.G-S); La Caixa Research Health grant HR23-00793 (to G.M. and A. B-G); the Canadian Institutes for Health and Research (FDN-148440 to J.S.B); The Basque Government (IT1620-22 to P.G); Atención Primaria, Cronicidad y Promoción de la Salud, Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III (RD21/0009/0006 to P.G)
dc.format.mimetype application/pdf
dc.identifier.citation Gómez-Sotres P, Skupio U, Dalla Tor T, Julio-Kalajzic F, Cannich A, Gisquet D, et al. Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice. Nat Commun. 2024 Aug 18;15(1):7103. DOI: 10.1038/s41467-024-51416-4
dc.identifier.doi http://dx.doi.org/10.1038/s41467-024-51416-4
dc.identifier.issn 2041-1723
dc.identifier.uri http://hdl.handle.net/10230/70857
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Nat Commun. 2024 Aug 18;15(1):7103
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/786467
dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Astrocyte
dc.subject.keyword Olfactory bulb
dc.subject.keyword Stress and resilience
dc.title Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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