NeuroHeal reduces muscle atrophy and modulates associated autophagy

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• dc.contributor.author Marmolejo-Martínez-Artesero, Sara
• dc.contributor.author Romeo-Guitart, David
• dc.contributor.author Mañas García, Laura, 1991-
• dc.contributor.author Barreiro Portela, Esther
• dc.contributor.author Casas, Caty
• dc.date.accessioned 2020-10-07T06:37:17Z
• dc.date.available 2020-10-07T06:37:17Z
• dc.date.issued 2020
• dc.description.abstract Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastly, an in vitro model of myotube atrophy with Tumor Necrosis Factor-α (TNFα). In all these models, we observed that NeuroHeal reduced muscle atrophy and that SIRT1 activation seems to be required for that. The treatment downregulated some critical markers of protein degradation: Muscle Ring Finger 1 (MuRF1), K48 poly-Ub chains, and p62/SQSTM1. Moreover, it seems to restore the autophagy flux associated with denervation. Hence, we envisage a prospective use of NeuroHeal at clinics for different myopathies.
• dc.description.sponsorship This work was funded by the Ministerio de Economía y Competitividad of Spain under the grant number SAF 2014-59701. We are also grateful for the support of TERCEL and CIBERNED from the Instituto de Salud Carlos III of Spain.
• dc.format.mimetype application/pdf
• dc.identifier.citation Marmolejo-Martínez-Artesero S, Romeo-Guitart D, Mañas-García L, Barreiro E, Casas C. NeuroHeal reduces muscle atrophy and modulates associated autophagy. Cells. 2020 Jun 28; 9(7):1575. DOI: 10.3390/cells9071575
• dc.identifier.doi http://dx.doi.org/10.3390/cells9071575
• dc.identifier.issn 2073-4409
• dc.identifier.uri http://hdl.handle.net/10230/45413
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Cells. 2020 Jun 28;9(7):1575
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-59701
• dc.rights copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword NeuroHeal
• dc.subject.keyword Autophagy
• dc.subject.keyword Proteasome
• dc.subject.keyword Sirtuin 1
• dc.subject.keyword Skeletal muscle atrophy
• dc.title NeuroHeal reduces muscle atrophy and modulates associated autophagy
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion