A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference
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- dc.contributor.author Cramer, Dinaca
- dc.contributor.author Serrano Pubull, Luis, 1982-ca
- dc.contributor.author Schaefer, Martin H.ca
- dc.date.accessioned 2017-04-20T12:09:03Z
- dc.date.available 2017-04-20T12:09:03Z
- dc.date.issued 2016
- dc.description.abstract Copy number alterations (CNAs) in cancer patients show a large variability in their number, length and position, but the sources of this variability are not known. CNA number and length are linked to patient survival, suggesting clinical relevance. We have identified genes that tend to be mutated in samples that have few or many CNAs, which we term CONIM genes (COpy Number Instability Modulators). CONIM proteins cluster into a densely connected subnetwork of physical interactions and many of them are epigenetic modifiers. Therefore, we investigated how the epigenome of the tissue-of-origin influences the position of CNA breakpoints and the properties of the resulting CNAs. We found that the presence of heterochromatin in the tissue-of-origin contributes to the recurrence and length of CNAs in the respective cancer type.
- dc.description.sponsorship The research leading to these results received funding from the German Research Foundation (SCHA 1933/1-1), the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013–2017’, SEV-2012–0208, the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreements n° HEALTH-F4-2011–278568 (PRIMES), from the Spanish Ministerio de Economía y Competitividad (Plan Nacional BIO2012-39754) and from the European Fund for Regional Development (EFRD).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Cramer D, Serrano L, Schaefer MH. A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference. eLife. 2016;5:e16519. DOI: 10.7554/eLife.16519. DOI: 10.7554/eLife.16519
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.16519
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/30857
- dc.language.iso eng
- dc.publisher eLifeca
- dc.relation.ispartof eLife. 2016;5:e16519
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/278568
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV2012-0208
- dc.rights © Copyright Cramer et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cancer genomics
- dc.subject.keyword Copy number alterations
- dc.subject.keyword Human
- dc.subject.keyword Tissue-specificity of disease
- dc.title A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preferenceca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion