The PRALINE database: protein and Rna humAn singLe nucleotIde variaNts in condEnsates

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  • dc.contributor.author Vandelli, Andrea
  • dc.contributor.author Arnal, Magdalena
  • dc.contributor.author Monti, Michele
  • dc.contributor.author Fiorentino, Jonathan
  • dc.contributor.author Broglia, Laura
  • dc.contributor.author Colantoni, Alessio
  • dc.contributor.author Sanchez de Groot, Natalia
  • dc.contributor.author Torrent Burgas, Marc
  • dc.contributor.author Armaos, Alexandros, 1989-
  • dc.contributor.author Tartaglia, Gian Gaetano
  • dc.date.accessioned 2023-03-20T07:20:20Z
  • dc.date.available 2023-03-20T07:20:20Z
  • dc.date.issued 2023
  • dc.description.abstract Biological condensates are membraneless organelles with different material properties. Proteins and RNAs are the main components, but most of their interactions are still unknown. Here, we introduce PRALINE, a database for the interrogation of proteins and RNAs contained in stress granules, processing bodies and other assemblies including droplets and amyloids. PRALINE provides information about the predicted and experimentally validated protein–protein, protein–RNA and RNA–RNA interactions. For proteins, it reports the liquid–liquid phase separation and liquid–solid phase separation propensities. For RNAs, it provides information on predicted secondary structure content. PRALINE shows detailed information on human single-nucleotide variants, their clinical significance and presence in protein and RNA binding sites, and how they can affect condensates’ physical properties.
  • dc.description.sponsorship This work was supported by the ERC [ASTRA_855923] and H2020 projects [IASIS_727658 and INFORE_825080].
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Vandelli A, Arnal M, Monti M, Fiorentino J, Broglia L, Colantoni A, et al. The PRALINE database: protein and Rna humAn singLe nucleotIde variaNts in condEnsates. Bioinformatics. 2023 Jan;39(1):btac847. DOI: 10.1093/bioinformatics/btac847
  • dc.identifier.doi http://dx.doi.org/10.1093/bioinformatics/btac847
  • dc.identifier.issn 1367-4803
  • dc.identifier.uri http://hdl.handle.net/10230/56268
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.ispartof Bioinformatics. 2023 Jan;39(1):btac847
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/855923
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825080
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/727658
  • dc.rights © The Author(s) 2023. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Biologia humana
  • dc.subject.other Biomolècules
  • dc.subject.other Proteïnes
  • dc.title The PRALINE database: protein and Rna humAn singLe nucleotIde variaNts in condEnsates
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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