Sensational placodes: neurogenesis in the otic and olfactory systems
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- dc.contributor.author Maier, Esther C.ca
- dc.contributor.author Saxena, Ankurca
- dc.contributor.author Alsina i Español, Bertaca
- dc.contributor.author Bronner, Marianne E.ca
- dc.contributor.author Whitfield, Tanya T.ca
- dc.date.accessioned 2015-06-04T06:56:53Z
- dc.date.available 2015-06-04T06:56:53Z
- dc.date.issued 2014ca
- dc.description.abstract For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. In this review, we outline many of the proteins and pathways that play essential roles in the differentiation of otic and olfactory neurons and their integration into their non-neuronal support structures. In both cases, well-known signaling pathways together with region-specific factors transform thickened ectodermal placodes into complex sense organs containing numerous, diverse neuronal subtypes. Olfactory and otic placodes, in combination with migratory neural crest stem cells, generate highly specialized subtypes of neuronal cells that sense sound, position and movement in space, odors and pheromones throughout our lives.en
- dc.description.sponsorship ECM was funded by a Marie Curie Intra European Fellowship(275978). This work was supported by the following grants: BFU2011-27006 to BA, NIH grants DE16459 and DC011577 to MEB, and a BBSRC project grant BB/J003050 to TTWen
- dc.format.mimetype application/pdfca
- dc.identifier.citation Maier EC, Saxena A, Alsina B, Bronner ME, Whitfield TT. Sensational placodes: neurogenesis in the otic and olfactory systems. Developmental Biology. 2014;389(1):50-67. DOI: 10.1016/j.ydbio.2014.01.023ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.ydbio.2014.01.023
- dc.identifier.issn 0012-1606ca
- dc.identifier.uri http://hdl.handle.net/10230/23727
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Developmental Biology. 2014;389(1):50-67
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-27006
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/275978
- dc.rights © 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 International http://creativecommons.org/licenses/by-nc-nd/3.0/ http://dx.doi.org/10.1016/j.ydbio.2014.01.023en
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
- dc.subject.keyword Oticen
- dc.subject.keyword Olfactoryen
- dc.subject.keyword Neurogenesisen
- dc.subject.keyword Hair cellen
- dc.subject.keyword Sensory neuronen
- dc.subject.other Laberint (Orella) -- Anatomiaca
- dc.subject.other Neurobiologia del desenvolupamentca
- dc.title Sensational placodes: neurogenesis in the otic and olfactory systemsen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca