Quality of dietary fat intake and body weight and obesity in a mediterranean population: secondary analyses within the PREDIMED trial

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  • dc.contributor.author Beulen, Yvette
  • dc.contributor.author Martínez-González, Miguel Ángel, 1957-
  • dc.contributor.author van de Rest, Ondine
  • dc.contributor.author Salas-Salvadó, Jordi
  • dc.contributor.author Sorlí, José Vicente
  • dc.contributor.author Gómez-Gracia, Enrique
  • dc.contributor.author Fiol, Miquel
  • dc.contributor.author Estruch, Ramón
  • dc.contributor.author Santos-Lozano, José
  • dc.contributor.author Schröder, Helmut, 1958-
  • dc.contributor.author Alonso-Gómez, Ángel
  • dc.contributor.author Serra-Majem, Luis
  • dc.contributor.author Pinto, Xavier
  • dc.contributor.author Ros, Emilio
  • dc.contributor.author Becerra-Tomás, Nerea
  • dc.contributor.author González, José I.
  • dc.contributor.author Fitó Colomer, Montserrat
  • dc.contributor.author Martínez, José Alfredo
  • dc.contributor.author Gea, Alfredo
  • dc.date.accessioned 2019-06-25T07:44:43Z
  • dc.date.available 2019-06-25T07:44:43Z
  • dc.date.issued 2018
  • dc.description.abstract A moderately high-fat Mediterranean diet does not promote weight gain. This study aimed to investigate the association between dietary intake of specific types of fat and obesity and body weight. A prospective cohort study was performed using data of 6942 participants in the PREDIMED trial, with yearly repeated validated food-frequency questionnaires, and anthropometric outcomes (median follow-up: 4.8 years). The effects of replacing dietary fat subtypes for one another, proteins or carbohydrates were estimated using generalized estimating equations substitution models. Replacement of 5% energy from saturated fatty acids (SFA) with monounsaturated fatty acids (MUFA) or polyunsaturated fatty acids (PUFA) resulted in weight changes of -0.38 kg (95% Confidece Iinterval (CI): -0.69, -0.07), and -0.51 kg (95% CI: -0.81, -0.20), respectively. Replacing proteins with MUFA or PUFA decreased the odds of becoming obese. Estimates for the daily substitution of one portion of red meat with white meat, oily fish or white fish showed weight changes up to -0.87 kg. Increasing the intake of unsaturated fatty acids at the expense of SFA, proteins, and carbohydrates showed beneficial effects on body weight and obesity. It may therefore be desirable to encourage high-quality fat diets like the Mediterranean diet instead of restricting total fat intake.
  • dc.description.sponsorship The PREDIMED trial (www.predimed.es) was supported by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Health, through grants provided to research networks specifically developed for the trial, namely, RTIC G03/140 (Coordinator: R. Estruch, M.D., Ph.D., during 2003-2005) and RTIC RD 06/0045 (Coordinator: M.A. Martínez-González, M.D., Ph.D., during 2006-2013). We also acknowledge CIBERobn (an Initiative of ISCIII), the grants from Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, Fondo de Investigación Sanitaria—Fondo Europeo de Desarrollo Regional (PI04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505), Ministerio de Ciencia e Innovación (AGL-2009-13906-C02, AGL2010-22319-C03), Fundación Mapfre 2010, Consejería de Salud de la Junta de Andalucía (PI0105/2007), Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109, GVACOMP2010-181, GVACOMP2011-151, CS2010-AP-111, CS2011-AP-042, and PROMETEO17/2017), and Regional Government of Navarra (P27/2011).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Beulen Y, Martínez-González MA, van de Rest O, Salas-Salvadó J, Sorlí JV, Gómez-Gracia E. et al. Quality of dietary fat intake and body weight and obesity in a mediterranean population: secondary analyses within the PREDIMED trial. Nutrients. 2018 Dec 19;10(12). pii: E2011. DOI: 10.3390/nu10122011
  • dc.identifier.doi http://dx.doi.org/10.3390/nu10122011
  • dc.identifier.issn 2072-6643
  • dc.identifier.uri http://hdl.handle.net/10230/41859
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13906-C02
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03
  • dc.rights Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Body weight
  • dc.subject.keyword Cohort study
  • dc.subject.keyword Fat
  • dc.subject.keyword Obesity
  • dc.subject.keyword Substitution models
  • dc.title Quality of dietary fat intake and body weight and obesity in a mediterranean population: secondary analyses within the PREDIMED trial
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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