Maternal seafood consumption during pregnancy and cardiovascular health of children at 11 years of age

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• dc.contributor.author Pinar-Martí, Ariadna
• dc.contributor.author Fernández-Barrés, Sílvia
• dc.contributor.author Lázaro, Iolanda
• dc.contributor.author Fossati, Serena
• dc.contributor.author Fochs, Silvia
• dc.contributor.author Pey, Núria
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Romaguera Bosch, Dora
• dc.contributor.author Sala Vila, Aleix
• dc.contributor.author Júlvez Calvo, Jordi
• dc.date.accessioned 2025-04-09T06:46:30Z
• dc.date.available 2025-04-09T06:46:30Z
• dc.date.issued 2024
• dc.description.abstract Nutrition is critical during pregnancy for the healthy growth of the developing infant, who is fully dependent on maternal dietary omega-3 supply for development. Fatty fish, a main dietary source of omega-3, is associated with decreased cardiovascular risk in adults. We conducted a longitudinal study based on a mother-offspring cohort as part of the project Infancia y Medio Ambiente (INMA) in order to assess whether fish intake during pregnancy relates to cardiovascular health in children. A total of 657 women were included and followed throughout pregnancy until birth, and their children were enrolled at birth and followed up until age 11-12. A semi-quantitative food frequency questionnaire was used to assess the daily intake of foods during the 1st and 3rd trimesters of pregnancy. Cardiovascular assessments included arterial stiffness (assessed by carotid-femoral pulse wave velocity [PWV]) and retinal microcirculation (photographic assessment of central retinal arteriolar and venular equivalent [CRAE and CRVE]). The association between maternal fish consumption and cardiovascular outcomes of offspring at 11 years of age was evaluated using multivariable linear regression models. There were no statistically significant differences in any cardiovascular endpoint in children whose mothers had a higher fish consumption during pregnancy compared to those with a lower fish consumption. We found a slightly higher PWV (β = 0.1, 95% CI = 0.0; 0.2, p for trend = 0.047) in children whose mothers had a higher consumption of canned tuna during the 1st trimester of pregnancy. Fish intake during pregnancy was found to be unrelated to the offspring's cardiovascular health at 11 years of age. The beneficial cardiovascular effects of fish consumption during pregnancy on the offspring are still inconclusive.
• dc.description.sponsorship This study was funded by Instituto de Salud Carlos III via the projects “CP14/00108, PI16/00261, and PI21/00266” (co-funded by the European Union Regional Development Fund “A way to make Europe”). This study was also funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI17/01340 incl. FEDER funds; and PI18/00547 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794 and 634453). We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency via the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S) and support from the Generalitat de Catalunya via the CERCA Program. The funders had no role in the study design, collection, management, analysis, and interpretation of data, writing of the report, or decision to submit it for publication.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pinar-Martí A, Fernández-Barrés S, Lázaro I, Fossati S, Fochs S, Pey N, et al. Maternal seafood consumption during pregnancy and cardiovascular health of children at 11 years of age. Nutrients. 2024 Mar 27;16(7):974. DOI: 10.3390/nu16070974
• dc.identifier.doi http://dx.doi.org/10.3390/nu16070974
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/70115
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Nutrients. 2024 Mar 27;16(7):974
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cardiovascular health
• dc.subject.keyword Children health
• dc.subject.keyword Fish intake during pregnancy
• dc.subject.keyword Maternal nutrition
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Omega-3
• dc.subject.keyword Pregnancy
• dc.title Maternal seafood consumption during pregnancy and cardiovascular health of children at 11 years of age
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion